李力

李力,理学博士,副研究员。

北京大学理学学士,军事医学科学院理学博士,英国牛津大学博士后,曾任军事医学科学院助理研究员,中国科学院副研究员。长期从事疾病生物学研究工作,曾在Nat Genet、Nat Cell Biol、Gut、Nat Commun、Genes Dev、PNAS、PLoS Biol、J Med Chem等国际著名期刊发表约30篇SCI论文。其中以第一或通讯作者发表SCI论文11篇,SCI累计影响因子近120。

 

Tel: 021-62933629

E-mail: lil@@sjtu.edu.cn




教育背景

1999年北京大学理学学士

2005年军事医学科学院理学博士

工作经历

2005年2008年,军事医学科学院,助理研究员

2009年至2011年,英国牛津大学,博士后

2012年至2015年,中国科学院上海高等研究院/上海生命科学研究院,副研究员

研究方向
肿瘤发生机制和干预;疾病动物模型和发育生物学。
科研项目

曾作为负责人承担2 项国家自然科学基金面上项目,2项科技部重大新药创制,1 项上海市科委基金,1 项横向课题和教育部留学归国人员启动基金,并作为骨干参与1 973 项目。

目前作为负责人承担1 项国家自然科学基金委面上项目,2 项上海市科委基金,2项国家重点实验室开放课题,1 项上海交通大学医工交叉基金和2项横向课题,并作为骨干参与1 项国家自然基金重点项目和1 项上海市科委重点项目。

代表性论文专著

1. Rao H, Li X, Liu M, Liu J, Feng W, Xu J, Gao WQ*, Li L*. SETD2 deficiency promotes renal cell carcinoma formation through Wnt/β-catenin signaling in mice. (*Co-corresponding author, In preparation)

2. Rao H#, Li X#, Liu M, Liu J, Li X, Xu J, Li L*, Gao WQ*. Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the Mitogen-Activated Protein Kinase Pathway in the Absence of von Hippel-Lindau. Oncogene. (*Co-corresponding author, IF: 6.6, Revised)

3. Liu M#, Sun T#, Li N, Peng J, Fu D, Li W, Li L*, Gao WQ*. BRG1 Attenuates Colonic Inflammation and Tumorigenesis through Autophagy-dependent Oxidative Stress Sequestration. Nat. Commun., 2019, 10: 4614. (*Co-corresponding author, IF: 11.9)

4. Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J*, Li L*, Gao WQ*, Zhu HH*. The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nat. Commun., 2019, 10(1): 3353. (*Co-corresponding author, IF: 11.9)

5. Niu N#, Lu P#, Yang Y, He R, Zhang L, Shi J, Wu J, Yang M, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, Sun YW*, Li L*, Xue J*. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis. Gut. (*Co-corresponding author, IF: 17.9, In Press)

6. Xu Q#, Xiang Y#, Wang Q#, Wang L#, Brind’Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nat. Genet., 2019, 51(5): 844-56. (*Co-corresponding author, IF: 27.1)

7. Wang L#, Niu N#, Li L#, Shao R, Ouyang H, Zou W*. H3K36 trimethylation mediated by SETD2 regulates bone marrow mesenchymal cell fate. PLoS Biol., 2018, 16(11): e2006522. (#Co-1st author, IF: 9.1)

8. Zuo X#, Rong B#, Li L#, Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J Biol. Chem., 2018, 293(24): 9188-97. (#Co-1st author, IF: 4.0 )

9. Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L*, Wei W*. A Ursolic Acid-derived Small Molecule Triggers Cancer Cell Death Through Hyperstimulation of Macropinocytosis. J Med. Chem., 2017, 60(15): 6638-48. (*Co-corresponding author, IF: 6.3)

10. Shi Y, Sun L, Chen G, Zheng D, Li L*, Wei W*. A combination of the telomerase inhibitor, BIBR1532, and taxol synergistically inhibit cell proliferation in breast cancer cell lines. Target. Oncol. 2015, 10(4): 565-73. (*Co-corresponding author, IF: 4.0)

11. Li L#, Wang D#, Xue M#, Mi X, Liang Y, Wang P*. 3'UTR shortening identifies high-risk prostate cancers with targeted dysregulation of ceRNA netwok. Sci. Rep., 2014, 4: 5406. (#Co-1st author, IF: 5.1)

12. Mould A#, Morgan MA#, Li L#, Bikoff EK, Robertson EJ*. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev., 2012, 26(18): 2063-74. (#Co-1st author, IF: 12.4)

13. Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L*, He F*. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol., 2009, 11(5): 580-91.

14. Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L*, He F*. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol., 2008, 10(8): 994-1002.

15. Li L#, Deng B#, Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y, Zhang L*, Yang X*, He F*. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc. Natl. Acad. Sci. USA., 2007, 104(19): 7951-6. [Comment: PACT regulates p53 controlled network of genes. Proc. Natl. Acad. Sci. USA., In this issue, 2007, 104(19): 7731-2] (#Co-1st author, IF: 10)


教学工作

生物医学工程学院"人类疾病动物模型"

博士生致远荣誉课程"分子纳米医学工程"

致远学院"生物化学"


荣誉奖励

北京市科学技术一等奖(2017

北京细胞生物学会首届青年优秀论文二等奖(2009

中国细胞生物学学会第九次会员代表大会青年优秀论文三等奖(2007

联系方式

邮箱地址:lil@@sjtu.edu.cn

联系电话:86-21-62933629

办公地址:教三楼 502室