注册登录 联系我们中文English
疾病生物学 当前所在位置:首页 >> 师资队伍 >> 教师名录 >> 疾病生物学

李力

时间:2016-07-19

理学博士,副研究员。研究方向为:肿瘤发生机制;疾病动物模型和发育生物学。1999年北京大学获理学学士学位。2005年军事医学科学院获理学博士学位。2009年至2011年在英国牛津大学进行博士后研究工作。2012年至2015年在中国科学院任副研究员。长期从事疾病生物学研究工作,曾在NCB,PNAS,GenesDev,Plos Biol,JMC,JBC等国际著名期刊发表20多篇SCI论文。其中以第一或通讯作者发表SCI论文7篇,SCI累计影响因子近50。曾作为负责人承担2 项国家自然科学基金面上项目,2项科技部重大新药创制,1 项企业横向课题和教育部留学归国人员启动基金,并作为骨干参与1 项973 计划。曾获得北京市科学技术一等奖(2017),北京细胞生物学会首届青年优秀论文二等奖(2009),中国细胞生物学学会第九次会员代表大会青年优秀论文三等奖(2007)。目前作为负责人承担1 项国家自然基金面上项目,2 项上海市科委项目,1 项上海交通大学医工交叉项目和1项医院横向基金,并作为骨干参与1 项国家自然基金重点项目和1 项上海市科委重点项目。


代表性研究论文:

1. Rao H, Li X, Liu M, Liu J, Li L*, Gao WQ*. Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the Mitogen-Activated Protein Kinase Pathway in the Absence of von Hippel-Lindau. Cancer Res., 2018. (*Co-corresponding author,IF: 9.1, Under Review)

2. Xu Q, Xiang Y, Wang Q, Wang L, Zhang Y, Zhang B, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Wu M, Li W*, Li L*, Xie W*.SETD2 governs maternal epigenomic reprogramming and fertility. Nat. Cell Biol., 2018. (*Co-corresponding author,IF: 19.1, Revised)

3. Wang L#, Niu N#, Li L#, Shao R, Ouyang H, Zou W. H3K36 trimethylation mediated by SETD2 regulates bone marrow mesenchymal cell fate. Plos Biol., 2018. (#Co-1st author, IF: 9.1, Accepted)

4. Zuo X#, Rong B#, Li L#, Lv R, Lan F, Tong MH. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J Biol. Chem., 2018, 293(24): 9188-97 (#Co-1st author, IF: 4.0 )

5. Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L*, Wei W*. A Ursolic Acid-derived Small Molecule Triggers Cancer Cell Death Through Hyperstimulation of Macropinocytosis. J Med. Chem., 2017, 60(15): 6638-48.(*Co-corresponding author,IF: 6.3)

6. Shi Y, Sun L, Chen G, Zheng D, Li L*, Wei W*. A combination of the telomerase inhibitor, BIBR1532, and taxol synergistically inhibit cell proliferation in breast cancer cell lines. Target. Oncol. 2015, 10(4): 565-73. (*Co-corresponding author,IF: 4.0)

7. Li L#, Wang D#, Xue M#, Mi X, Liang Y, Wang P. 3'UTR shortening identifies high-risk prostate cancers with targeted dysregulation of ceRNA netwok. Sci. Rep., 2014, 4: 5406. (#Co-1st author, IF: 5.6)

8. Mould A#, Morgan MA#, Li L#, Bikoff EK, Robertson EJ. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev., 2012, 26(18): 2063-74. (#Co-1st author, IF: 12.4)

9. Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L, He F. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol., 2009, 11(5): 580-91.

10. Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol., 2008, 10(8): 994-1002.

11. Li L#, Deng B#, Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y,Zhang L,Yang X, He F. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc. Natl. Acad. Sci. USA., 2007, 104(19): 7951-6. [Comment: PACT regulates p53 controlled network of genes. Proc. Natl. Acad. Sci. USA., In this issue, 2007, 104(19): 7731-2] (#Co-1st author, IF: 10)


版权所有Copyright@2016上海交通大学生物医学工程学院    地址:上海市徐汇区华山路1954号    沪交ICP备05227