1. Dr. Dan Czajkowsky
Dr. Dan Czajkowsky received his B.Sc. in Physics in 1992 from the University of Alberta, Canada and his Ph.D. in Biophysics in 2000 from the University of Virginia, USA. From 2000 to 2009, he was a Research Associate at the University of Virginia and then arrived in China in 2010 as a Young International Scientist Fellow at the Chinese Academy of Sciences, working with Dr. Jun Hu at the Shanghai Institute of Physical Biology, where he remained until 2012. In 2013, he joined the School of Biomedical Engineering at the Shanghai Jiao Tong University where he is now a Professor. He has authored 68 publications and 4 patents.
(1) Bacterial pore-forming toxins: their pore-forming mechanism, strategies by which they can be inhibited for therapy, and their development in biomedical applications
(2) The mechanism by which IgM activates complement C1q and the development of polymeric Fc-fusions for therapy.
(3) The structural principles underlying interphase and metaphase 3D chromosomal architecture using super-resolution optical microscopy and sequencing-based approaches.
(4) Development of novel single-molecule based instrumentation, including a cryogenic AFM specifically for biological samples and a multiplex magnetic tweezers device for mechanical phenotyping of cells
(1) Meng, Y., Yi, X., Li, X., Hu, C., Wang, J., Bai, L., Czajkowsky, D.M.* and Shao, Z*. The non-coding RNA composition of the mitotic chromosome by 5’-tag sequencing. Nucleic Acids Research 44, 4934-4946 (2016) (*Co-corresponding author).
(2) Czajkowsky, D.M., Sun, J., Shen, Y., and Shao, Z. Single molecule compression reveals intra-protein forces drive cytotoxin pore formation. eLife e08421 (2015).
(3) Yang, L., Czajkowsky, D.M.*, Sun, J., Hu, J., and Shao, Z*. Anomalous nanoscale surface fatigue in a layered material. Advanced Materials 26, 6478-6482 (2014). (*Co-corresponding author)
(4) Czajkowsky, D.M.*, Li, L.*, Sun, J., Hu, J., and Shao, Z. Critical role of proton “fingers” and subsurface atoms in determining adsorbed protein orientation ACS Nano 6, 190-198 (2012). (*Co-first author)
(5) Czajkowsky, D. M. and Shao, Z. The human IgM pentamer is a mushroom-shaped molecule with a flexural bias. Proceedings of National Academy of Sciences USA 106, 14960-14965 (2009).
2. Dr. Tsung-Yuan Tsai
Dr. Tsung-Yuan Tsai received his M.S. and Ph.D. degrees from the Institute of Biomedical Engineering of National Taiwan University in 2004 and 2010. Dr. Tsai won a talent-student-study-abroad scholarship to work with Professor Andrew Amis in Imperial College London in U.K. in 2008. Dr. Tsai was a research fellow/instructor, working with Professor Guoan Li, at the Bioengineering Laboratory in Harvard Medical School, Massachusetts General Hospital in Boston, U.S.A. from 2011 to 2016. He joined the School of Biomedical Engineering of Shanghai Jiao Tong University as the Professor of Special Appointment in 2016. He also currently serves as the Principle Scientist in the Medical 3D Printing Center at Shanghai Ninth People‘s Hospital, Medical School of Shanghai Jiao Tong University. His research interests span Imaging Biomechanics, Orthopaedic Engineering, Sports Science, Motion Analysis, and Computational Biomechanics. Dr. Tsai has published more than 50 peer-reviewed journal articles and 130 professional conference papers. He is the co-author of 2 book chapters, including The Hip Kinematics in “Adult Hip”, and Applications Using MATLAB in “Introduction to Finite Element Analysis”. He is Active Member of Orthopaedic Research Society of the US. He is an invited reviewer for 12 Science Citation Index journals.
1. To tackle clinical issues and evaluate in-vivo/in-vitro functional performance of the human neuromusculoskeletal system using computational biomechanics, medical imaging methods, optical stereophotogrammetry, magnetic tracking techniques, and the inertial measurement unit.
2. To design innovative medical devices using additive or subtractive Manufacturing (3D Printing or Computer Numerical Control) for unmet clinical needs in Orthopaedics, Physical Therapy, Occupational Therapy, Rehabilitation, Sports Medicine and etc.
1. T.-Y. Tsai, D. Dimitriou, M.H. Liow, H. Rubash, G. Li, Y.-M. Kwon*. 3D Imaging Analysis of Unicompartmental Knee Arthroplasty Evaluated in Standing Position: Component Alignment and In-Vivo Articular Contact. The Journal of Arthroplasty, 2016, 31(5), 1096-1101.
2. T.-Y. Tsai, D. Dimitriou, A. Hosseini, G. Li, Y.-M. Kwon*. Assessment of Accuracy and Precision of 3D Reconstruction of Unicompartmental Knee Arthroplasty in Upright Position Using Biplanar Radiography, Medical Engineering and Physics, 2016 Jul; 38(7):633-8.
3. T.-Y. Tsai, J.-S. Li, D. Dimitriou, G. Li, Y.-M Kwon*. Does Haptic-Robot Assisted Total Hip Arthroplasty Better Restore Native Hip Acetabular and Femoral Anatomy? The International Journal of Medical Robotics and Computer Assisted Surgery, 2016 Jun; 12(2):288-95.
4. T.-Y. Tsai, J.-S. Li, D. Dimitriou, Y.-M Kwon*. Does Component Alignment Affect Gait Symmetry in Unilateral Total Hip Arthroplasty Patients? Clinical Biomechanics, 2015, Oct; 30(8): 802-7.
5. T.-Y. Tsai, D. Dimitriou, J.-S. Li, K. W. Nam, G. Li*, Y.-M. Kwon. Asymmetric Hip Kinematics during Gait in Unilateral Total Hip Arthroplasty Patient, J Biomechanics, 2015, Feb 26; 48(4):555-9.
3. Dr. Yao Chen
Dr. Yao Chen received the B.S. degree in 1996 in physiology and biophysics from Peking University, Beijing, China, and the Ph.D. degree in 2001 in biophysics from Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. From 2001 to 2009, he worked at Mount Sinai School of Medicine and SUNY – College of Optometry in New York City for his post-doctoral training. He studied neuronal mechanism of visual attention by training monkeys doing attention tasks in different difficulties, and recording neuronal activity in visual cortex with chronically implanted micro-electrode array. His result was reported as a cover story in Nature Neuroscience. In 2010, he became a Professor of Special Appointment in Shanghai Jiao Tong University continuing his research in cognitive neuroscience and brain-machine interface. Then he was promoted to be a tenured professor in 2016. Dr. Chen has been involved in a number of research projects from the Chinese National Natural Science Foundation and has authored or coauthored 27 referred papers, 1 book chapter, and 1 patent.
(1) Neuronal mechanism of brain cognition functions, such as visual attention, learning and memory.
(2) Neural information processing in biomedical engineering, including retinal prosthesis and brain-machine interface.
(3) Fundamental principles of how the brain executes actions for related neurological and psychiatric diseases.
(1) Huang, D.; Xue, L.Y.; Wang, X.; Chen, Y.*; Using spatial uncertainty to manipulate the size of the attention focus. Scientific Reports. 2016, 6, 32364.
(2) Ma, Z.G.; Cao, P.J.; Sun, P.C.; Zhao, L.N.; Li, L.M.; Tong, S.B.; Lu, Y.L.; Yan, Y.; Chen, Y.*#; Chai, X.Y.#; Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation. Scientific Reports. 2016; 6: 21627. (#:co-corresponding authors)
(3) Wang, M.J.; Wang, X.H.; Xue, L.Y.; Huang, D.; Chen, Y.*; Visual attention modulates the asymmetric influence of each cerebral hemisphere on spatial perception. Scientific Reports, 2016, 6, 19190.
(4) Li, X.*#; Chen, Y.*#; Lashgari, R.; Bereshpolova, Y.; Swadlow, H.A.; Lee, B.B.; Alonso, J.-M.; Mixing of chromatic and luminance retinal signals in primate area V1. Cerebral Cortex. 2015, 25(7): 1920-1937. (#: equal contribution)
(5) Chen, Y.*; Martinez-Conde, S.; Macknik, S.L.; Bereshpolova, Y.; Swadlow H.A.; Alonso, J.-M.; Task difficulty modulates the activity of specific neuronal populations in primary visual cortex. Nature Neuroscience, 2008, 11, 974-982. (Cover paper of this issue and previewed by Dr. John H. Reynolds in the same issue, pages 861-862)
4. Dr. Xianting Ding
Dr. Xianting Ding is professor at School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University. He received his Ph.D. degree from Department of Mechanical Engineering at University of California, Los Angeles (UCLA) in 2012. His research interests focus on developing personalized diagnostic and therapeutic technology, including: 1) developing bio-sensors for early detection of cancer, infectious disease, metabolic diseases, and cardiovascular diseases, based on cellular electrochemical, impedance, mechanical and photonic signaling; 2) developing personalized treatment and optimizing drug combinations based on Feedback System Control (FSC), Microfluidics and Bio-MEMS; 3) Traditional Chinese Medicine (TCM) modernization, extraction, purification, and re-combination for treating ischemia, osteoporosis and depression.
He participated in the early investigation and development for 3 international research centers, including Institute for Cell Mimetic Space Exploration (CMISE, funded by NASA), Center for Cell Control (CCC, funded by NIH) and Institute for Personalized Medicine (IPM, funded by Chinese Central Organization). He is the editorial board member for Scientific Reports and Journal of the Association for Laboratory Automation (JALA) and reviewer for 10 journals. He has published 50 peer reviewed journal papers and filed 30 national or international patents.
(1) Single-cell multi-targeting detection：We are developing mass cytometry (also named, CyTOF) technique for single-cell analysis. CyTOF is a mass spectrometry technique based on inductively coupled plasma mass spectrometry combined with mass tags that allows accurate measuring of various molecular species on single cells in a highly multiplexed fashion.
(2) Portable bio-sensors for disease diagnosis: We are developing portable bio-sensors with microfluidics, bio-electrochemistry, hydrogel and surface modification skills for point-of-care technologies (POCT).
(3) Large-scale drug combination optimization: We are interested in developing enabling techniques to facilitate the optimization of large-scale drug candidates for potent therapy. These techniques allow identification of effective drug combination therapies both for a population or an individual with minimal experimental efforts.
(1) W. Liu#, M. Zhang, X. Liu, A. Sharma, X. Ding*, “A Point-of-Need infrared mediated PCR platform with compatible lateral flow strip for HPV detection”, Biosensors and Bioelectronics, 96:213-219, 2017
(2) S. Liu#, W. Su, Z. Li, X. Ding*, “Electrochemical detection of lung Cancer specific microRNAs using 3D DNA origami nanostructures”, Biosensors and Bioelectronics, 71: 57-61, 2015
(3) Z. Li#, W. Su, S. Liu, X. Ding*, “An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH”, Biosensors and Bioelectronics, 69: 287-293, 2015
(4) W. Liu#, Y. Li, X. Ding*, Cell adhesion pattern created by OSTE polymers, Biofabrication, 9(2):025006, 2017
(5) A. Weiss#, R. Berndsen, X. Ding*, C. Ho, P. Dyson, H. Bergh, A. Griffioen, P. N. Sliwinska*, “A streamlined search technology for identification of synergistic drug combinations”, Scientific Reports, 5: 14508, 2015
5. Dr. Yiping Du
Dr. Yiping Du received the Ph.D. degree in physics in 1995 at the University of Utah, USA. He was a scientist at the Applied Science Lab at General Electric Company from 1995 to 1999. He was a faculty member in radiology at the University of Chicago from 2000-2002. He joined the University of Colorado School of Medicine as an associate professor in psychiatry and radiology and technical director of the Brain Imaging Center in 2002. He was promoted to professor in 2009. He joined the College of Biomedical Engineering at Zhejiang University as a full-time professor, endowed by the “1000 talent” program during 2010-2015. He is now the director of the Institute for Medical Imaging Technology and Zhiyuan chair professor at the School of Biomedical Engineering, Shanghai Jiao Tong University. He is now a deputy editor of Magnetic Resonance in Medicine and a senior member of IEEE-EMBS. He served as the president of the Overseas Chinese Society of Magnetic Resonance in Medicine (2014-2015). He is a recipient of Stauffer Award from the Associate of the University Radiologists in USA.
(1) Quantitative magnetic resonance imaging (MRI), molecular imaging, PET-MR, novel acquisition techniques of MRI, pulse sequence design, clinical applications of MRI.
(2) Design and fabrication of RF and gradient coils, design of low-field MR systems.
(1) Ye H, Ma D, Jiang Y, Cauley SF, Du YP, Wald LL, Griswold MA, Setsompop K. Accelerating magnetic resonance fingerprinting (MRF) using t-blipped simultaneous multislice (SMS) acquisition. Magn Reson Med. 2016;75:2078-85.
(2) Du YP, Chu R, Tregellas JR, Enhancing the Detection of BOLD Signal in fMRI by Reducing Partial Volume Effect, Computational and Mathematical Methods in Medicine, 2014;2014, Article ID 973972,
(3) Hwang D, Kim D, Du YP. In vivo multislice mapping of myelin water content using T2* decay. NeuroImage, 2010;52:198-204.
(4) Du YP, Jin Z, Robust tissue-air volume segmentation of MR images based on the statistics of phase and magnitude: Its applications in the display of susceptibility weighted imaging of the brain, J Magn Reson Imaging. 2009;30:722-731.
(5) Du YP, Jin Z, Hu Y, Tanabe J. Multi-echo MR angiography and venography in the brain at 3T, J Magn Reson Imaging. 2009;30:449-454.
(6) Hwang D, Du YP, Improved myelin water quantification using spatially regularized nonnegative least squares algorithm. J Magn Reson Imaging. 2009;30:203-208.
(7) Jin Z, Xia L, Du YP. Reduction of Artifacts in Susceptibility Weighted MR Venography of the Brain. J Magn Reson Imaging. 2008;28:327-33.
(8) Du YP, Jin Z. Simultaneous acquisition of MR angiography and venography (MRAV). Magn Reson Med. 2008;59:954-8.
(9) Du YP, Chu R, Hwang D, Brown MS, Kleinschmidt-DeMasters BK, Singel D, Simon JH. Fast multislice mapping of the myelin water fraction using multicompartment analysis of T2* Decay at 3T – A preliminary postmortem study. Magn Reson Med. 2007;58:865-70.
6. Prof. Wei-Qiang Gao
Prof. Wei-Qiang Gao received his Ph.D. from Columbia University in 1989 and did his post-doctoral research at Columbia University and the Rockefeller University. From 1993-2010. He had been a Scientist, and Senior Scientist and Group at Genentech, Inc.. Dr. Gao has made important contributions to the fields of tumorigenesis, stem cells and neuroscience. In early 1990’s, he made important contributions to the mechanisms of cerebellar granule neuronal differentiation. His group then pioneered research on development and regeneration of inner ear hair cells at Genentech and changed the traditional view that mammalian inner ear hair cells cannot regenerate. He was invited to speak at the Nobel Conference “To Restore Hearing” organized by the Karolinska Institute in Sweden in 2002. More recently, his group worked on “cancer research and cancer stem cells” and “stem cells and tissue regeneration” and published a paper in Nature in 2008 to report for the first time that a single adult stem cell is capable of generating a functional prostate organ. Dr. Gao has published 80 papers as either corresponding or the first author, including Nature, Cell, Science, Neuron, Nature Neuroscience, Nature Communications, Gastroenterology, PNAS, etc. and has been granted 48 US patents. He is a scholar of national “Thousand-Talents Program”, and the Chief Scientist of two program projects from the Ministry of Science and Technology of China and 2 Key grants from the National Natural Science Foundation of China. He has served as a reviewer for grant proposals of Wellcome Trust in UK, NIH in US, and NSFC and 35 journals including Nature, Nature Medicine, Nature Cell Biology, Nature Communications, Cancer Cells, PNAS, etc..
1. Tumorigenesis and therapeutic resistance
2. Stem cells and tissue repair
3. Cochlear hair cell regeneration
1. Chen Q, Quan Y, Wang N, Xie C, Ji Z, He H, Chai R, Li H, Yin S, Chin YE, Wei X, Gao WQ.Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea. Stem Cell Reports. 2017 Jul 11;9(1):231-246.
2. Zhang K, Guo Y, Wang X, Zhao H, Ji Z, Cheng C, Li L, Fang Y, Xu D, Zhu HH, Gao WQ. WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells. Cancer Res. 2017 May 1;77(9):2534-2547.
3. Zhang C, Ji Z, Wang M, Zhang W, Yang R, An H, Yang R, van Abel D, van Dijk M, Yang X, Ou G, Zhu HH, Gao W-Q. Stox 1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation. Cell Death and Differentiation, 2016 Dec;23(12):2042-2053.
4. Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH and Gao W-Q .Shp2 promotes metastasis of prostate cancer by attenuating thePAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene 2016, 35:1271-82.
5. Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ.Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports. 2015 Nov 10;5(5):816-28.
6. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao WQ.CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Oct 15;75(20):4312-21.
7. Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ. Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nature Communications. 2014 Aug 28;5:4758.
8. Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY and Gao WQ. Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat. Stem Cell Reports. 2014 Jun 19;3(1):101-14.
9. Leong KG, Wang BE, Johnson L, Gao WQ. Generation of a prostate from a single adult stem cell. Nature. 2008 Dec 11;456(7223):804-8.
10. Zheng JL, Gao WQ. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nature Neuroscience. 2000 Jun;3(6):580-6.
7. Prof. Hongchen Gu
Prof. Hongchen Gu is the Associate Dean at School of Biomedical Engineering of Shanghai Jiao Tong University. He received his Ph.D. degree in Chemical Engineering in 1992 from East China University of Science and Technology. From 1994 to 1995, he joined Pennsylvania State University as a visiting professor. From 2008 until now, Dr. Gu served as the Director of Nano-biomedical Research Center at School of Biomedical Engineering.
Prof.Gu and his group have already industrialized a number of achievements to clinic application, including high sensitivity nucleic acid assay for blood screening and infectious disease. Dr. Gu has published more than 200 peer-review articles and applied for more than 30 patents. He has received several awards including the Second Prize of Shanghai Technology Invention Award (2013), and the Second Prize of Natural Science Award of Ministry of education (2015).
(3) Controlled synthesis of nanomaterials, surface modification and its applications in biomedical science.
(4) Interactions of nanomaterials and bio-molecules.
(5) Nanomaterials for diagnostics and therapy technology.
1) Ding Sheng-zi Zhang, Yang Jiang, Haiou Yang, Youjie Zhu, Shunjia Zhang, Ying Zhu,Dan Wei1, Ye Lin, PingPing Wang, Qihua Fu, Hong Xu*, Hongchen Gu*, Dual-Encoded Microbeads through a Host-Guest Structure: Enormous, Flexible and Accurate Barcodes for Multiplexed Assays, Advanced Functional Materials, 2016, 26, 6146-6157
2) Ying Zhu, Hong Xu, Kaimin Chen, Jianping Fu and Hongchen Gu*，Encoding through Host/Guest Structure: Construction of Multiplexed Fluorescent Beads，Chemical Communications，23/09/2014; 50(90),14041-14044
3) Yao Wang and Hongchen Gu*，Core–Shell-Type Magnetic Mesoporous Silica Nanocomposites for Bioimaging and Therapeutic Agent Delivery，Advanced Materials, 2015, 27(3):576-585 (Highly cited paper)
4) Li Lin, Hongchen Gu* and Jian Ye*，Plasmonic multi-shell nanomatryoshka particles as highly tunable SERS tags with built-in reporters，Chemical Communications，12th October 2015，51（100）:17740-17743
5) Yijie Chen, Hongchen Gu*, Ding Sheng-Zi Zhang, Fan Li , Tengyuan Liu,Weiliang Xia*,Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier，Biomaterials，December 2014 35(38)，10058–10069
8. Dr. Hao He
Dr. Hao He is a full-time professor in Shanghai Jiao Tong University (SJTU). He got the B.S. from the special class for the gifted young in the University of Science and Technology of China in 2006 and the PhD degree in the Chinese University of Hong Kong in 2010 respectively. Since 2011, he worked as an associate professor in the Ultrafast laser Laboratory in Tianjin University. Since 2014, he joined the School of Biomedical Engineering in SJTU. His research focuses on Biophotonics, specifically on the precise stimulation and modulation of cellular signaling and functions by femtosecond lasers, novel microscopy systems, and applications of such technologies in medial fields. He has published more than 20 SCI-indexed peer-reviewed papers as the first or corresponding author on Nature Photonics and other top journals, and 3 book chapters. He is now an adjunct professor in Tianjin University and owns Lectureship in the University of Tokyo. His research has been supported by the NSFC funding, and awarded as the JSPS oversea fellowship.
(1) Laser-induced differentiation of stem cells
(2) Optical regulation of cell calcium signaling
(3) Multiphoton microscopy of brain in vivo
1. Hao He, Keiichi Nakagawa, Yisen Wang, Yoichiro Hosokawa, Keisuke Goda. Mechanism for microtsunami-induced intercellular mechanosignalling. Nature Photonics 9, 623 (2015)
2. Hao He*, S Li, S Wang, M Hu, Y Cao, and C Wang. Manipulation of cellular light from green fluorescent protein by a femtosecond laser. Nature Photonics 6, 651-656 (2012).
3. YS Wang, Hao He*, S Li, B Lan, Y Cao, M Hu, C Wang. All-optical regulation of gene expression in targeted cells. Scientific Reports, 4, 5346 (2014).
4. Hao He, K.T. Chan, S.K. Kong, R.K.Y. Lee. All-optical human cell fusion by a fiber femtosecond laser. Applied Physics Letters 93, 163901 (2008).
5. Hao He, S.K. Kong, R.K.Y. Lee, Y.K. Suen, K.T. Chan. Targeted photoporation and transfection in human HepG2 cells by a fiber femtosecond laser at 1554 nm. Optics Letters 33, 2961-2963 (2008).
9. Qiu Huang
Qiu Huang received the B.S. and M.S. degrees in Automation Engineering from the University of Jiangsu, China, and the Ph.D. degree in Electrical Engineering from the University of Utah, Salt Lake City under the supervision of Prof. G. Larry Zeng. She then joined Prof. Grant Gullberg's group at the Lawrence Berkeley National Laboratory as a postdoctoral research fellow. Since July 2009, she has been with the School of Biomedical Engineering, Shanghai Jiao Tong University, and is now an Associate Research Professor. She is also an Adjunct research professor at the Department of Nuclear Medicine, Ruijin Hospital. She has been involved in a number of research projects and has authored or coauthored more than 50 scientific papers and 6 patents.
1. The inverse problems in Medical Imaging, including reconstruction algorithms (both analytical and iterative algorithms) for SPECT/PET/CT, Ultrasound vector tomography, and MRI diffusion tensor tomography.
2. Nuclear Medicine Imaging Instrumentation: SPECT system development, collimator design, PET system development
3. Medical Image Processing and Analysis: Kinetic modeling, statistical modeling, segmentation, registration
1. Zan Y, Long Y, Chen K, Li B, Huang Q* and Gullberg GT. Design of a short non-uniform acquisition protocol for quantitative analysis in dynamic cardiac SPECT imaging – a retrospective 123I-MIBG animal study, Medical Physics, on press, 2017
2. Zhao Z, Huang Q*, Gong Z, Su Z, Moses W, Xu J* and Peng P*. A noval read-out electronics design based on 1-bit Sigma-Delta modulation, IEEE trans. Nucl. Sci., 2017, 64:820-828
3. Weng F, Bagchi S, Zan Y, Huang Q*, Seo Y*. An energy-optimized collimator design for a CZT-based SPECT camera. Nucl. Inst. and Methods in Physics Research, A. : Accelerators, Spectrometers, Detectors and Associated Equipment，2016，806：330-339
4. Yang Z, Zan Y, Zheng X, Hai W, Chen K, Huang Q*, Xu Y* and Peng J*. Dynamic FDG-PET Imaging to Differentiate Malignancies from Inflammation in Subcutaneous and in situ Mouse Model. Plos One. 2015; 10(9)
5. Zan Y, Boutchko R, Huang Q*, Li B*, Chen K and Gullberg GT. Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic SPECT Imaging Shows the Potential for Early Diagnosis of Heart Failure. Molecular Imaging, 2015; 14:1535-3508
10. Dr. Ning Lan
Dr. Ning Lan, Professor of School of Biomedical Engineering, Executive Associate Director of the institute of rehabilitation engineering, and Director of Laboratory of NeuroRehabilitation Engineering at SJTU. He obtained his Ph.D. degree in Biomedical Engineering from Case Western Reserve University in 1989. Then he served as assistant professor and associate professor in University of Kentucky and University of Southern California.
His research interests include: Neural control of movements and neural musculoskeletal modeling; neural rehabilitation engineering and functional electrical stimulus; neural modulation and treatment of neurologic diseases. He has advanced the hypothesis of “α-γ” model of neural control of movements; expanded the multi-scale system’s model of computational sensorimotor control; verified a propriospinal neuron model in the spinal cord for processing descending motor control signals; elucidated the neural mechanism of a non-invasive stimulation protocol for inhibiting tremor in Parkinson’s disease; developed the distributed electrical stimulating system based on body area network; evaluated a rehabilitation strategy of functional electrical stimulation based on muscle synergy for patients post stroke; assessed the phenomenon of evoked tactile sensation in upper limb amputees, and further proposed a noninvasive sensory feedback pathway for prosthetic hand. During the past years, he has served as PI for a number of grants from the Natural Science Foundation of China (NSFC), the 973 National Basic Research Project of Ministry of Science and Technology (MOST), National 985 project III on translational medicine research funding etc. Prof. Ning Lan has been named as the most cited authors in Biomedical Engineering in China from 2014 to 2016 consecutively. He served as the guest associate editor of Frontiers of Computational Neuroscience and organized the research topic on Neural and Computational Modeling of Movement Control.
(1). Neural Engineering and Neuromodulation:
Animal studies to evaluate the effectiveness of electrical stimulation of sacral spinal cord for bladder dysfunctions in spinal cord injury, developing next generation of neuromodulation technology to treat the conditions in Parkinson’s disease, and restoring sensory feedback for prosthetic limbs by transcutaneous electrical nerve stimulation (TENS).
(2). Neural Control of Movement and Biomechanics
Modeling sensorimotor control functions and biomechanics of movements, in particular, the roles of proprioceptive afferents in posture and movement control; Computational approach to understanding the functions of basal ganglia-spinal circuitry in discrete reaching movements; Experimental test of the dual control hypothesis for postures and movements.
(3). Rehabilitation Engineering:
Design functional electrical stimulation (FES) systems to retrain and restore motor functions for patients with stroke and spinal cord injury; Modeling and simulation of neuromuscular control system using functional electrical stimulation (FES) to restore limb movements; Neural networks for EMG-based control of neuroprosthetic functions.
1. Si Li*, Cheng Zhuang*, Chuanxin M. Niu, Yong Bao, Qing Xie and Ning Lan, Evaluation of Functional Correlation of Task-Specific Muscle Synergies with Motor Performance in Patients post Stroke. Frontiers in Neurology (2017). doi: 10.3389/fneur.2017.00337.
2. Man-Zhao Hao*, Shao-Qin Xu*, Zi-Xiang Hu*, Fu-Liang Xu*, Chuanxin M. Niu, Qin Xiao and Ning Lan, Inhibition of Parkinsonian Tremor with Cutaneous Afferent Evoked by Transcutaneous Electrical Nerve Stimulation, Journal of Neuroengineering and Rehabilitation(Accepted), Jun.2017.
3. Hong-En Qu*, Si Li*, Man-Zhao Hao*, Zi-Xiang Hu*, Chuanxin M. Niu and Ning Lan, Corticospinal Gating of Central Oscillation in Generating Action Tremors, Neural Regeneration Research (in press), March. 2017.
4. N. Lan, V.C.K. Cheung and S. C. Gandevia, Editorial – Neural and Computational Modeling of Movement Control, Front. Comput. Neurosci. (2016) 10:90. doi: 10.3389/fncom.2016. 00090
5. H.E. Qu*, Y.J. Xie*, X.X. Liu*, X. He*, M.Z. Hao*, Y. Bao, Q. Xie, and N. Lan, Development of Network-Based Multichannel Neuromuscular Electrical Stimulation System for Stroke Rehabilitation, Journal of Rehabilitation Research & Development 53(2):263-278, 2016.
6. Xin He*, Man-Zhao Hao*, Ming Wei, Qin Xiao, and Ning Lan, Contribution of Inter-Muscular Synchronization in the Modulation of Tremor Intensity in Parkinson’s Disease, J. of Neuroengineering and Rehabilitation (2015) 12:108 DOI 10.1186/s12984-015-0101-x
7. S. Li*, X. He*, M.Z. Hao*, N. Lan, Coordinated Alpha and Gamma Control of Muscles and Spindles in Movement and Posture, Front. Comput. Neurosci. (2015) 9:122. doi: 10.3389 /fncom.2015.00122
8. Guohong Chai*, Xiaohong Sui, Si Li*, Longwen He, and Ning Lan, Characterization of Evoked Tactile Sensation in Forearm Amputees with Transcutaneous Electrical Nerve Stimulation, J. Neural Eng. 12 (2015) 066002, doi:10.1088/1741-2560/12/6/066002
9. S. Li*, G.H. Chai*, X.H. Sui, N. Lan, Finite Element Modeling of Cutaneous Electrical Stimulation for Sensory Feedback, Chinese Journal of Biomedical Engineering (English Edition), vol.23 (4), Dec. 2014.
10. Y.J. Xie*, X.X. Liu*, H.E. Qu* and N. Lan, Design and Implementation of a Wearable Body Area Sensor Network for Distributed FES System, Chinese Journal of Biomedical Engineering (English Edition), vol.23 (4), Dec. 2014.
11. G.H. Chai*, X.X. Sui, P. Li，X.X. Liu*, N. Lan, Review on Tactile Sensory Feedback of Prosthetic Hands for the Upper-Limb Amputees by Sensory Afferent Stimulation, Journal of Shanghai Jiaotong University (Science), 2014, DOI: 10.1007/s12204 -009-0501-3
12. P. Shi*, X.Y. Zhao*, and J.W. Wang and N. Lan, Effects of Acute Sacral Neuromodulation on Bladder Reflex in Complete Spinal Cord Injury Rats, Neuromodulation: Technology at the Neural Interface, 2013,16:583-589, doi: 10.1111/j.1525-1403.2012.00528.x
13. M.Z. Hao*, X. He*, Q. Xiao, B. Alstermark and N. Lan, Corticomuscular Transmission of Tremor Signals by Propriospinal Neurons in Parkinson’s Disease, PLOS ONE 8(11): e79829. doi:10.1371/journal.pone.0079829, 2013.
14. X He*, Y.F. Du* and N Lan, Evaluation of Feedforward and Feedback Contributions to Stiffness and Variability in Multi-Joint Arm Control, IEEE Trans. on Neural Systems and Rehabilitation Engineering, VOL. 21, NO. 4, pp. 634-647, JULY 2013. DOI: 10.1109/ TNSRE.2012.2234479
15. H.E. Qu*, X. He*, Y. Bao, Y.J. Xie*, Q. Xie and N. Lan, Research and Development of Personalized Rehabilitation Technology, World Rehabilitation Engineering and Devices, November 2012.
16. X.Y. Zhao*, M.Z. Hao*, P. Shi* and N. Lan, Neuromodulation Technologies and Applications, World Rehabilitation Engineering and Devices, June 2012.
17. N. Lan and X. He*, Fusimotor Control of Spindle Sensitivity Regulates Central and Peripheral Coding of Joint Angles, Frontiers in Computational Neuroscience, August 2012, doi:10.3389/fncom.2012.00066.
18. Zhao* XY, Shi* P, Sun YH, and Lan N, Evaluation of a rat model of bladder dysfunction induced by complete spinal transection, Chinese J. Rehab. Medicine, 27(2):99-102, 2012.
11. Dr. Haiyan Li
Dr. Haiyan Li received the B.E. degree in 1999 and the M.S. degree in 2002 in Chemical Engineering from Hubei Polytechnic University, Hubei, China, and the Ph.D. degree in 2005 in Materials Engineering from Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai. From 2005 to 2006, she was at Unilevel (Shanghai) Ltd. as a Material Engineer. From 2006 to 2008, she carried out a postdoc research project in Monash University, Melbourne, Australia. From 2008 to 2011, she had been a Postdoctoral Fellow of the INSERM U1026 (577), Bordeaux, France. She joined the School of Biomedical Engineering of Shanghai Jiao Tong University as an associate professor in 2011. She has been involved in a number of industrial and European research projects and has authored or coauthored 59 peer-reviewed SCI papers, 2 book chapters, and 8 patents. Dr. Li has received a number of awards, including Scholar of “Pu Jiang” from the Shanghai Government (2013), and Scholar of “Morning Star” from Shanghai Jiao Tong University (A, B and C grades).
(1) Research and development of biomaterials for vascularization of tissue engineering, including skin regeneration, bone tissue engineering, cartilage tissue engineering etc.
(2) Mechanism study of cell-cell interactions and materials/cell-cell study for enhancing tissue regeneration.
(3) Mechanism study of effects of biomaterial stimulatory signals on tissue regeneration.
(1) Dong X, Chang J, Li HY*. Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells. J Mater Chem B, 2017, 5, 5240 – 5250.
(2) Xu YC, Peng JL, Dong X, Xu YH, Li HY*, Chang J*. Combined chemical and structural signals of biomaterials synergistically activates cell-cell communications for improving tissue regeneration. Acta Biomater, 55:249-261, 2017.
(3) Li HY, He J, Yu HF, Green CR and Chang J. Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior. Biomaterials, 84: 64-75, 2016.
(4) Yu HF, Peng JL, Xu YH, Chang J and Li HY*. Bioglass activated skin tissue engineering constructs for wound healing. ACS Appl Mater Interfaces, 8: 703-715, 2016.
(5) Li HY, Xue K, Kong N, Liu K and Chang J. Silicate bioceramics enhanced vascularization and osteogenesis through stimulating interactions between endothelia cells and bone marrow stromal cells. Biomaterials 35: 3803-3818, 2014.
(6) Li HY and Chang J. Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect. Acta Biomater 9: 6981-6991, 2013.
12. Dr. Yao Li
Dr. Yao Li received her B.S. degree from Shanghai Jiao Tong University in 2002, and her Ph.D. degree from the State University of New York at Stony Brook in 2008. She then worked in Stony Brook medical center as a postdoctoral associate. She joined the School of Biomedical Engineering and Med-X research institute in Shanghai Jiao Tong University as an associate professor in 2010. Dr. Li was supported by many research agencies including the National Science Foundation in China, Ministry of Science and Technology, Ministry of Education of China, and Shanghai Municipal Science and Technology Committee, etc. She is the associate editor of BMC Neuroscience. She is a member of Institute of Electrical and Electronics Engineers (IEEE) and Organization of Human Brain Mapping (OHBM). Dr. Li was granted the “SMC Outstanding Young Faculty Award of Shanghai Jiao Tong University” (2016), and “Fei Xiang Young Faculty Talent Program of Shanghai Association for Science and Technology” (2015).
(1) Magnetic resonance spectroscopy
(2) Multimodal functional magnetic resonance imaging study in mental disorders (e.g., OCD, schizophrenia, etc) and stroke
(3) Cerebral blood flow imaging
(1) Li, Yao，Chen, Zengai，Su, Xin，Zhang, Xiaoliu，Wang, Ping，Zhu,
Yajing，Xu, Qun，Xu, Jianrong，Tong, Shanbao(*)，Functional lateralizationin cingulate cortex predicts motor recovery after basal ganglia stroke，Neuroscience Letters，2016，613（2）：6-12。
(2) Yajing Zhu, Qing Fan, Haiyin Zhang, Jianyin Qiu, Ling Tan, Zeping Xiao, Shanbao Tong, Jue Chen and Yao Li*, “Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study”, BMC Psychiatry, 2016,16:104.
(3) Xiaoliu Zhang,Yingying Tang,Mirjana Maletic-Savatice,Jianhua Sheng, Xuanhong Zhang, Yajing Zhu, Tianhong Zhang, Junjie Wang, Shanbao Tong, Jijun Wang, Yao Li*, “Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: an fMRI-MRS study”, Journal of Affective Disorders, 2016, 201:153-161.
ng,Zongfeng，Tan,Ling，Xiao,Zeping，Tong,Shanbao，Maletic-Savatic, Mirjana，Li,Yao*，Decreased thalamic glutamate level in unmedicated adult obsessive compulsive disorder patients detected by proton magnetic resonance spectroscopy，Journal of Affective Disorders，2015，178：193-200。
(5) Manganas, Louis N ，Zhang, Xueying，Li, Yao，Hazel, Raphael D，Smith, S David，Wagshul, Mark E，Henn, Fritz，Benveniste, Helene，Djuric, Petar M，Enikolopov, Grigori，Maletic-Savatic, Mirjana*，Magnetic resonance spectroscopy identifies neural progenitor cells in the live human
13.Dr. Guan Ning Lin
Dr. Guan Ning Lin, a principle investigator (PI) and Professor of Special Appointment (Eastern Scholar) at the School of Biomedical Engineering since 2016. He received his BS/MS of Computer Science at Baylor University (USA), PhD of Bioinformatics at University of Missouri (USA) and as a Postdoc fellow at University of California, San Diego (USA). His main research effort has been the development and application of new analytic methods that elucidate the underlying network organization in multi-dimensional data, permitting integration of genomic and genetic data with phenotype data on a large scale. One area of basic investigation has been in the analysis of transcriptome data where he uses network biology approaches to understand brain transcriptome organization, which connects genetic risk for disease in autism to brain circuitry and molecular function both in humans, and in vitro and in vivo model systems. The goal is to develop effective therapeutics for neurologic and psychiatric disorders, including autism and schizophrenia. In recent years, Dr. Lin has published various research paper in high impact journals, including Nature Communication, Neuron, Cell, American Journal of Human Genetics, etc.
Lab website: http://bmi.sjtu.edu.cn/
(1) Translation Bioinformatics, Systems biology
(2) Neuropsychiatric informatics (Autism, Schizophrenia, Bipolar, etc)
(3) Machine learning & statistical inference on high-throughput biological datasets
1. GN Lin, R Corominas, H Nam, J Urresti, LM Iakoucheva. Comprehensive analysis of tissue-specific networks with implications to psychiatric diseases. Methods in Molecular Biology. 2017.
2. KA Pagel, V Pejaver, GN Lin*, H Nam, M Mort, DN Cooper, J Sebat, LM Iakoucheva, SD Mooney and P Radivojac. When loo-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants. Bioinformatics. 2017.
3. GN Lin, R Corominas, I Lemmens, X Yang, J Tavernier, DE Hill, M Vidal, J Sebat, LM Iakoucheva. Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases. Neuron. 2015 Feb 18;85(4):742-54. (Issue Highlights)
4. R Corominas*, X Yang*, GN Lin*, S Kang*, Y Shen, SA Wanamaker, S Tam, M Rodriguez, M. Broly, J Sebat, K Salehi-Ashtiani, DE Hill, M Vidal, T Hao and LM Iakoucheva. Protein interaction network of alternatively-spliced isoforms from brain links genetic risk factors for autism. Nature Communication, 2014 April 5:3650.5. GN Lin, C Zhang, and D Xu. Polytomy identification in microbial phylogenetic reconstruction. BMC System Biology, 2011 Dec 23:5.
Dr. Jie Luo, Associate Professor, School of Biomedical Engineering, Shanghai Jiao Tong University. B.S. in Chemistry in 2007 Peking University, Ph.D. in 2012 Washington University in St. Louis. In 2013, she joined Research Lab of Electronics at Massachusetts Institute of Technology as a postdoctoral fellow, and in 2015, the Fetal-Neonatal Neuroimaging and Developmental Science Center (FNNDSC) at Boston Children’s Hospital, Harvard Medical School as a research fellow. Dr. Luo is currently supported by grants from the Ministry of Science and Technology. Dr. Luo has been a member of the International Society for Magnetic Resonance in Medicine (ISMRM) and Overseas Chinese Society of Magnetic Resonance in Medicine (OCSMRM) since 2009, and was elected Junior Fellow of the ISMRM Society in 2016. She serves as ad-hoc reviewer for journals of NMR in Biomedicine, Magnetic Resonance in Medicine, and the Journal of Developmental Origins of Health and Disease.
(1) Development of MRI technologies, sequence design, biophysical models, quantification
(2) applications of novel MR approaches clinical applications, such as neurological diseases, interaction between environment and neurodevelopment in early life.
(1) J. Luo#, E. Abaci Turk#, C. Bibbo, B. Gagoski, D. J. Roberts, M. Vangel, C. M. Tempany-Afdhal, C. Barnewolt, J. Estroff, A. Palanisamy, W. H. Barth, C. Zera, N. Malpica, , P. Golland, E. Adalsteinsson, J. N. Robinson, P. E. Grant*, In vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. Scientific Reports, 2017; DOI: 10.1038/s41598-017-03450-0.
(2) E. Abaci Turk#, J. Luo#, B. Gagoski, J. Pascau, C. Bibbo, J. N. Robinson, P. E. Grant, E. Adalsteinsson, P. Golland, N. Malpica*, Spatiotemporal alignment of in utero BOLD-MRI series. Journal of Magnetic Resonance Imaging, 2017; DOI: 10.1002/jmri.25585
(3) D. Mamah*, J. Wen, J. Luo, X. Ulrich, D. M. Barch, D. A. Yablonskiy, Subcomponents of brain T2* relaxation in schizophrenia, bipolar disorder and siblings: A Gradient Echo Plural Contrast Imaging (GEPCI) study. Schizophrenia Research, 2015; 169:36-45.
(4) J. Luo, X. He and D. A. Yablonskiy*, Nature of MR Signal Frequency Shift in White Matter ‐ Experimental Validation of Generalized Lorentzian Approach. Magnetic Resonance in Medicine, 2014; 71: 1251-1263.
(5) J. Luo, D. A. Yablonskiy, C. F. Hildebolt, S. Lancia, and, A. H. Cross*, Gradient echo MRI correlates with clinical measures and allows visualization of veins within multiple sclerosis lesions. Multiple Sclerosis Journal, 2014; 20:349-355.
15. Dr. Dahong Qian
Dr. Dahong Qian received his Ph.D. degree in 2002 from Harvard University, Cambridge, MA. He has over 15 years of experience in high tech industry.
(1) Deep learning-based medical image and other data analysis and diagnostics;
(2) Ultra low power sensors and wireless transmission for body area network;
(3) Point-of-care miniature biosensors and AI-based data analysis.
1) K. Jin, H. Lu, Z. Su, C. Cheng, J. Ye, D. Qian, “Telemedicine screening of retinal diseases with a handheld portable non-mydriatic fundus camera”, BMC Ophthalmology, 2017.
2) M. Zhou, K. Jin, S.Wang, J. Ye, D. Qian, ”Color Retinal Image Enhancement Based on Luminosity and Contrast Adjustment”, IEEE Transactions on Biomedical Engineering, 2017.
3) Wang SZ, Jin K, Lu HT, Cheng CM, Ye J, D. Qian, “Human Visual System-Based Fundus Image Quality Assessment of Portable Fundus Camera Photographs”, IEEE Transactions on Medical Imaging. 2016;35(4):1046-55.
Deng C, Sheng Y, Wang SY, Hu W, Diao SX, D. Qian, “A CMOS Smart Temperature Sensor with Single-Point Calibration Method for Clinical Use”, IEEE Transactions on Circuits and Systems II-Express Briefs. 2016;63(2):136-40.
16. Dr. Kun Qian
Dr. Kun Qian, Professor of Biomedical Engineering. BS/MS Fudan University, PhD The University of Queensland, Research Fellow Stanford University. He is now a principle investigator (PI) at School of Biomedical Engineering, Shanghai Jiao Tong University (since 2014). His research interests and efforts are focused on the development and commercialization of ultra-sensitive and high-throughput biotechnology and bio-analytical methods for diverse bio-molecules in biomedical applications through design, synthesis and engineering of materials and devices.
He has co-authored over 50 peer-reviewed articles in top journals, including Nature Communications, Advanced Materials, Advanced Functional Materials, ACS Nano, et al. He has been funded by Natural Science Foundation China(NSFC) and hosted international young post-doc researchers continuously. He also received several prestigious domestic/international awards for research excellence, including NML Researcher Award (2016), Professor of Special Appointment (Eastern Scholar, 2015-2018), Shanghai Pujiang Talent Scheme (2014-2016), GE Foundation TECH Award in Hongkong (2011) et al. He had strong connections with domestic and international industry partners.
(1) materials and device
(2) mass spectrometry
(3) bio-molecular analysis
(4) disease diagnosis
(1) Huang, L., et al., and Qian, K.*, Nature Communications, 2017.
(2) Rejeeth, C., et al., and Qian, K.*, Nano Research, 2017.
(3) Liu, B., et al., and Qian, K.*, Advanced Functional Materials, 2016.
(4) Wu, J., et al., and Qian, K.*, Advanced Functional Materials, 2016.
(5) Qian, K., et al., ACS Nano, 2009.
17. Professor Zhifeng Shao
Professor Zhifeng Shao received his bachelor's degree in physics from Nanjing University in 1982 and Ph.D. degree in 1988 from University of Chicago under the supervision of Professor A. V. Crewe. He then joined the faculty of molecular physiology and biophysics at University of Virginia in 1989 and was appointed as full professor in 1998. He was elected Fellow of AAAS in 2000, Fellow of AIMBE in 2016 and is the K. C. Wong Chair professor in biomedical engineering at Shanghai Jiao Tong University since 2009. Professor Shao served as the director of Shanghai Center for Systems Biomedicine from 2009 to 2013 and is currently an Associate Dean of Biomedical Engineering at SJTU. Professor Shao had served on many US review panels, including NSF and NIH study sections, and is a member on the advisory panels at the Natural Science Foundation of China and MOST 973 program since he returned to China. His group has published more than 170 peer reviewed articles in scientific journals. Professor Shao also serves on several editorial boards, such as Journal of Microscopy and BioScience Trends and is an associate editor for Nanomedicine NMB.
(1) Molecular biophysics: single molecule structure and dynamics and super resolution of chromatin
(2) Functional genomics: metaplasia and cancer; non-coding RNA in gastric development and mitotic chromosome; nuclear structure
(3) Bio-instrumentation: cryo force imaging; Ultra-depth imaging of intact tissues and organs
1. Meng, Y., Yi, X., Li, X., Hu, C., Wang, J., Bai, L., Czajkowsky, D.M., Shao, Z. The non-coding RNA composition of the mitotic chromosome by 5'-tag sequencing. Nucleic Acids Research, 44, 4934-46 (2016).
2. Wei, X., Zhang, G., Shen, Y., Zhong, Y., Liu, R., Yang, N. Al-Mkhaizim, F.Y., Kline, M., He, L., Lu, Z.L., Shao, Z. and Gong, B. Persistent Organic Nanopores Amenable to Structural and Functional Tuning. Journal of the American Chemical Society, 138, 2749-54 (2016).
3. Guo, Y., Huang, A., Hu, C., Zhou, Y., Zhang, X., Czajkowsky, D.M., Gu, J., Liu, B. and Shao, Z. Complex Clonal Mosaicism within Intestinal Metaplastic Glands without Concurrent Gastric Cancer. Journal of Medical Genetics, 53, 643-646 (2016).
4. Czajkowsky, D.M., Sun, J., Shen,Y., Shao, Z. Single molecule compression reveals intra-protein forces drive cytotoxin pore formation. eLife, DOI: 10.7554/eLife.08421 (2015).
5. Yang, L., Czajkowsky, D.M., Sun, J., Hu, J. and Shao, Z. Anomalous Surface Fatigue in a Nano-Layered Material. Advanced Materials, 26, 6478–6482 (2014).
6. Gong, B. and Shao, Z. Self-assembling Organic Nanotubes with Precisely Defined, Sub-nanometer Pores: formation and mass transport characteristics. Accounts of Chemical Research 46, 2856–2866 (2013).
7. Czajkowsky, D.M., Li, L., Sun, J., Hu, J. and Shao, Z. Heteroepitaxial Streptavidin Nanocrystals Reveal Critical Role of Proton “Fingers” And Subsurface Atoms in Determining Adsorbed Protein Orientation. ACS Nano, 6, 190-198 (2012).
18. Dr. Guofeng Shen
Dr. Guofeng Shen, special research scientist, doctoral supervisor. Got PhD. in Instrument Science and Technology Departmrnt of Harbin Institute of Technology in 2004 and work as a postdoctor in BME department of Shanghai Jiao Tong University from 2004 to 2006. Finished postdoctor research work and appointed as a associate professor in 2006. Appointed as a visiting associate professor in Foucused Ultrasound Lab of Hardvard Medcial School, Harvard University since 2011-2012. Appointed as a special research scientist and doctoral supervisor in 2014. The chairman of program committee of ISTU 2013 Conference, the member of Instrument Committee of Chinese Society of Ultrasound Medical Engineering, the member of Youth Committee of Chinese Society of BME. Peer reviewer of Applied Acoustic and some other international professional journals. Hosted more than 20 projects, published over 70 papers, authorized 11 patents and 3 software copyrights. Won the 1st Shanghai Science and Technology Progress Award and 3rd Chinese Medical Committee Science and Technoloogy Progress Award. The main research include intelligence instrument, physical theatment technology and MR guided phased focused ultrasound technology. The first MR-PHIFU system was successfully developed and certificated by the Chinese authority inspection agency.
(1) Intelligent biomedical instrumentation and advanced physical therapeutic methods for tumor therapy
Biomedical ultrasound therapy
Ultrasound local thermo-chemotherapy
(2) MRI guided Phased High Intensity Focused Ultrasound(PHIFU) System for tumor therapy
Simulation of ultrasound and thermal field
Design of ultrasonic transducer and amplifier
Image orientation and guidance
Non invasive temperature measurement
Animal and clinical trials
Technology on PHIFU device
(1) Wu, Hao，Shen, Guofeng(*)，Chen, Yazhu，Feasibility of an electromagnetic compatibility method for MRgFUS using a wire mesh screen，Ultrasonics，2016.12.01，72：15~23
(2) Yu, Ying，Shen, Guofeng(*)，Zhou, Yufeng，Bai, Jingfeng，Chen, Yazhu，Quantitative Assessment of Acoustic Intensity in the Focused Ultrasound Field Using Hydrophone and Infrared Imaging，Ultrasound in Medicine and Biology，2013.11.01，39（11）：2021~2033
(3) Li, Dehui，Shen, Guofeng(*)，Bai, Jingfeng，Chen, Yazhu，Focus Shift and Phase Correction in Soft Tissues During Focused Ultrasound Surgery，IEEE Transactions on Biomedical Engineering，2011.6.01，58（6）：1621~1628
(4) Qiao, Shan，Shen, Guofeng(*)，Bai, Jingfeng，Chen, Yazhu，Transcostal high-intensity focused ultrasound treatment using phased array with geometric correction，Journal of the Acoustical Society of America，2013.8.01，134（2）：1503~1514
19. Junfeng Sun, PhD
Junfeng Sun, PhD, is an Associate Professor and Distinguished Research Fellow of biomedical engineering at School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University. He gained his Bachelor Degree (Electronic Science and Information Systems) and the Master Degree (Acoustics) from Nanjing University, and Ph. D degree (Electronic and Information Engineering) from the Hong Kong Polytechnic University. He has been a Visiting Research Associate (08.2012 - 08.2013) at Department of Biomedical Engineering, University of Minnesota. He is IEEE Senior Member, Guest Associate Editor of Frontiers in Aging Neuroscience, and referees for more than 20 international journals. He has published more than 30 papers in SCI journals. He is the principal investigator of grants from NSFC and co-investigator of grant from National Basic Research Program of China (973) and National Key Research and Development Program of China. He is also the awardee of the SMC-Morning Star Award for Young Investigator, Shanghai Jiao Tong University, 2011. He instructs the course Signal and Linear System for undergraduate students and the course Biomedical Signal Processing for graduated students.
Office Tel: +86-21-62933291
(1) Neuroimaging (EEG, fMRI, DTI) and brain network modeling
(2) Transcranial Ultrasound Stimulation and Transcranial Magnetic Stimulation,
(3) Applications of above techniques to Cognitive Function and Intervention for Depression, Stroke, Aging and other Mental Disorders.
 Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A. Lewin, Shanbao Tong, “Low-intensity (400 mWcm2, 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats”, Brain Stimulation, 10: 695-702, 2017.
 Lifu Deng, Junfeng Sun*, Lin Cheng, and Shanbao Tong, “Characterizing dynamic local functional connectivity in the human brain”, Scientific Reports, 6: 26976, 2016. (*通讯作者)
 Xiangfei Hong, Junfeng Sun, Jesse Bengson, George Mangun, and Shanbao Tong, “Normal aging selectively diminishes alpha lateralization in visual spatial attention”, Neuroimage, 106: 353-363, 2015.
 Junfeng Sun, Xiangfei Hong, and Shanbao Tong, “Phase synchronization analysis of EEG signals: An evaluation based on surrogate tests”, IEEE Transactions on Biomedical Engineering, 59(8): 2254-2263, 2012.
 Junfeng Sun* and Michael Small, “Unified framework for detecting phase synchronization in coupled time series”, Physical Review E, 80: 046219, 2009.
20. Dr. Shengxian Tu
Dr. Shengxian Tu is a Special Research Scientist, Professor of Special Appointment (Eastern Scholar), Young Yangtze River Scholar at the School of Biomedical Engineering. He received his master degree in Biomedical Engineering from Shanghai Jiao Tong University in 2008. After that, he joined the Medis Applied Research group as a scientific researcher, while at the same time pursuing a PhD degree at the Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center, the Netherlands. He graduated cum laude in February 2012. He is the inventor of several patents including the methods for computation of fractional flow reserve from coronary angiography (FFRQCA or QFR). He is also the founder of two software packages, being QAngio XA 3D Research Edition and QAngioOCT Research Edition, which are being used for clinical studies by a number of hospitals in Europe, Asia, and America. Over the past few years he has published several articles in the leading cardiovascular journals such as J Am Coll Cardiol, JACC Cardiovasc Interv, and Circ Cardiovasc Interv. In November 2014 he was accepted as a Fellow of European Society of Cardiology (FESC). Currently, he serves as an associate editor of the International Journal of Cardiovascular Imaging and a member of the Editorial Board of Journal of Geriatric Cardiology and Cardiovascular Diagnosis and Therapy. So far, he has authored or coauthored 49 peer-reviewed papers, 18 abstracts, 3 book chapters, and 12 patents. Dr. Tu is PI of a total of 6 approved grant applications in China for a total value of about $2M, including National Key R&D Program of China (2016).
Phone: +86-21- 62932631
Research interests: cardiovascular imaging and quantitative analysis, vascular hemodynamics, coronary intervention, fractional flow reserve, shear stress, optical coherence tomography.
Selected peer-reviewed articles:
1. Wu X., C. v. B., Takashi M., Li Y, Niels R. M., Johan H. C. Reiber, Tu S*. A novel four-dimensional angiogrephic approach to assess dynamic superficial wall stress of coronary arteries in vivo: Initial experience in evaluating vessel sites with subsequent plaque rupture. EuroIntervention. 2017. Epub ahead of print. DOI: 10.4244/eij-d-16-01020.
2. Tu S*, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JHC, Holm NR, Wijns W, FAVOR Pilot Trial Study Group. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study. J Am Coll Cardiol Interv 2016; 9:2024–35. [view]
3. Li Y, Gutiérrez-Chico JL, Holm NR, Yang W, Hebsgaard L, Christiansen EH, Mæng M, Lassen JF, Yan F, Reiber JHC, Tu S*. Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease: Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT. J Am Coll Cardio 2015; 66:125-35. [view]
4. Tu S*, Echavarria-Pinto M, von Birgelen C, Holm NR, Pyxaras SA, Kumsars I, Lam MK, Valkenburg I, Toth GG, Li Y, Escaned J, Wijns W, Reiber JHC. Fractional flow reserve and coronary bifurcation anatomy: A novel quantitative model to assess and report the stenosis severity of bifurcation lesions. J Am Coll Cardiol Interv 2015; 8:564-74. [view]
5. Tu S*, Barbato E, Koszegi Z, Yang J, Sun Z, Holm NR, Tar B, Li Y, Rusinaru D, Wijns W, Reiber JHC. Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: A fast computer model to quantify the functional significance of moderately obstructed coronary arteries. J Am Coll Cardiol Interv 2014, 7:768-777. [view]
6. Tu S*, Pyxaras SA, Li Y, Barbato E, Reiber JHC, Wijns W. In vivo flow simulation at coronary bifurcation reconstructed by fusion of 3-dimensional X-ray angiography and optical coherence tomography. Circ Cardiovasc Interv2013, 6:e15-e17. [view]
Dr.Jin-Ye Wang, Professor and Team Leader of Biomaterials Lab of Biomedical Engineering, Shanghai Jiaotong University (2009-). Received Ph.D. from Tohoku University, Japan (1992); the Hundred Talent Program of the Chinese Academy of Sciences (1999) and professor of Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (2000-2009); adjunct professor of Shanghai Jiaotong University (2003-2009).
She has published over 90 SCI papers, 4 books (chapters). One paper has been selected as Biomaterial Focus by Materials Today. 14 Chinese patents and one US patent were authorized. She was the invited speaker and session chair of European Conference on Biomaterials, et al. Awards include the Hundred Talent Program of the Chinese Academy of Sciences (1999), Life Sciences Prize from Meiji Dairies Corporation (2008), faculty adviser for excellence in Master Dissertation Research Paper (Shanghai Municipal Education Commission，2008), faculty adviser for excellence in Doctor Dissertation Research Paper (Shanghai Municipal Education Commission，2009) and faculty adviser for National Excellent Doctoral Dissertation of China (award nomination, Ministry of Education of China, 2010).
(1) Tissue Engineering: Preparation of porous scaffolds using advanced techniques such as electrospinning and 3D bioprinting for tissue regeneration (bone, vascular and sciatic nerve tissues); methodology for analysis of degrading mechanism of biodegradable materials in vivo.
(2) Controlled Release and Fluorescent Probe: Nano/micro-spheres and scaffolds for the delivery of drugs and biological molecules in a sustained, pulsatile, environmentally responsive manner; nano fluorescent probes for tracing drug target, stem cell proliferation, differentiation and tissue regeneration.
(3) Biomimetic Materials and Biointerfaces: Development of novel biomaterials inspired by nature (biomembrane mimic by phase-separation and self-assembly); understanding formation of two or three-dimensional ordered structure and related biomaterial-cell/tissue reaction studies and the regulating methods.
(1) Wang, H.J., Kato, S., Nakagawa, K., Kimura, F., Miyazawa, T.* and Wang, J.Y.* HPLC-MS/MS: a Potential Method to Track the in vivo Degradation of Zein-based Biomaterial, J. Biomed. Mater. Res. A, in press.
(2) Wang L.P.,Gotoh T., Wang Y.Z., Kouyama T., Wang J.Y.* Formation of a Mimetic Biomembrane from the Hydrophobic Protein Zein and Phospholipids: Structure and Application, J. Phys. Chem. C, 2017, 121(36), 19999–20006.
(3) Geng, S.Y., Wang, Y.Z., Wang, L.P., Kouyama, T., Gotoh, T., Wada, S. and Wang, J.Y.* A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System, Scientific Report, 2017, 7, 39202.
(4) Wang, G.W., Yang, H., Wu, W.F., Zhang, P. and Wang, J.Y.* Design and Optimization of a Biodegradable Porous Zein Conduit using Microtubes as a Guide for Rat Sciatic Nerve Defect Repair, Biomaterials, 2017, 132, 145-159.
(5) Wang, H.J., Huang, J.C., Hou, L., Miyazawa, T. and Wang, J.Y.* Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. Journal of Materials Science: Materials in Medicine, 2016, 27(5), 1-13.
(6) Wang, L.P., Huang, Q.W. and Wang, J.Y.* Nanostructured Polyaniline Coating on ITO Glass Promotes the Neurite Outgrowth of PC 12 Cells by Electrical Stimulation, Langmuir, 2015, 31(44), 12315–12322.
(7) Geng, S.Y., Yang, B., Wang, G.W., Qin, G., Wada, S. and Wang, J.Y.* Two cholesterol derivatives-based PEGylated liposomes as drug delivery system, study on pharmacokinetics and drug delivery to retina, Nanotechnology, 2014, 25 (27), 275103.
(8) Qin, G., Geng, S.Y., Wang, L.P., Dai, Y.Q., Yang, B. and Wang, J.Y.* Charge influence of liposome on transdermal delivery efficacy. Soft Matter, 2013, 9, 5649-5656.
(9) Han, Y.L., Xu, Q., Lu, Z.Q. and Wang, J.Y.* Cell adhesion on zein films under shear stress field. Colloid Surf. B: Biointerfaces, 2013, 111, 479-485.
(10) Di, L., Wang, L.P., Lu, Y.N., He, L., Lin, Z.X., Wu, K.J., Ren, Q.S. and Wang, J.Y. Protein adsorption and peroxidation of rat retinas under stimulation of a neural probe coated with polyaniline. Acta Biomaterialia, 2011, 7, 3738–3745.
22. Prof. Yongting Wang
Prof. Yongting Wang received her Ph.D. degree of Biochemistry from the University of Mississippi Medical Center in 2004. She studied protein subunit interaction and protein aggregation diseases as a post-doctoral fellow at MIT (2004-2008) before joining Med-X Research Institute of SJTU in 2008 as an Associate Professor (2008-2011). She is now a Professor in the School of Biomedical Engineering. Her current research focuses on strategies that promote neurovascular remodeling and functional recovery after ischemic stroke. Her research team developed gene therapy, adult stem cell therapy, gene-engineered stem cell therapy, and optogenetics techniques to enhance angiogenesis and neurogenesis in the ischemic brain. She had published more than 70 peer-reviewed research articles in high-impact journals including STROKE and JCBFM. She is the recipient of SMC Young Faculty Award (2009-2011), the Science and Technology Progress Award from the Ministry of Education (2013), and the NSFC Excellent Young Scientists Fund (2015). She is a member of the American Heart and Stroke Association and a Board member of the International Society for Cerebral Blood Flow & Metabolism (ISCBFM).
1. Gene therapy and engineered stem cell therapy of stroke;
2. Investigation of specific neurons in adult neurogenesis after stroke using optogenetics approach.
1. He, X., Y. Lu, X. Lin, L. Jiang, Y. Tang, G. Tang, X. Chen, Z. Zhang, Y. Wang*, and G.-Y. Yang*, Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion. Journal of Cerebral Blood Flow & Metabolism, 2017: p. 0271678X16642242.
2. Li Y, Tang G, Liu Y, He X, Huang J, Lin X, Zhang Z, Yang GY*, Wang Y*. CXCL12 Gene Therapy Ameliorates Ischemia-Induced White Matter Injury in Mouse Brain. Stem Cells Transl Med. 2015; 10:1122-30
3. Li Y, Huang J, He X, Tang G, Tang YH, Liu Y, Lin X, Lu Y, Yang GY*, Wang Y*. Postacute stromal cell-derived factor-1α expression promotes neurovascular recovery in ischemic mice. Stroke. 2014;45(6):1822-9.
4. He X, Li Y, Lu H, Zhang Z, Wang Y*, Yang GY*. Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2013; 33(12): 1921-7.
5. Huang J, Li Y, Tang Y, Tang G, Yang GY*, and Wang Y*. CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response after Focal Ischemia in Mice. Stroke 2013 44(1): 190-7
23. Prof. Weiliang Xia
Weiliang Xia, Ph.D., is currently Professor at School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University. He is also Associate Dean for both School of BME and Zhiyuan College at SJTU. Dr. Xia obtained his doctoral degree from the University of Hong Kong with predoctoral training at the Rockefeller University in New York City via a joint PhD program from 2003-2006, followed by a postdoctoral fellowship at the University of California,San Francisco from 2007 to 2008. He joined SJTU by the end of 2008. The research interest of his group includes cancer therapy by using multidisciplinary approaches; brain ischemia protection and tissue repair; and in particular the function of Sirtuin proteins in cancer progression and tissue repair. One of the finding of his research is identification of Sirt3 activator adjudin and its applications in neuroprotection in ischemic stroke models, and in cancer therapy. The recent focus of his group is on exosome isolation, characterization and use in cancer therapy. Dr. Xia has published more than 80 research papers since 2005, which have been cited over 3000 times with an H-index of 31 (Google Scholar). He has been awarded the Rising Star Prize by Shanghai Science and Technology Commission and SMC Young Faculty Award of SJTU. He is funded by National Natural Science Foundation of China and Ministry of Science and Technology. He is also a member of the Academic Committee of the university, a member of Youth Working Committee for the Chinese Cell Biology Society and Basic Research Group, Neurology Section of Shanghai Medical Association, and a member of American Association for Cancer Research and the Chinese Neuroscience Society.
Function of Sirtuins in cancer progression and tissue repair; cancer therapy by using multidisciplinary approaches including exosome isolation, characterization and use for cancer therapy; neuroprotection for ischemic stroke.
1) Li X, Xie QR, Zhang J, Xia W* and Gu H*. The packaging of siRNA within the mesoporous structure of silica nanoparticles. Biomaterials. 2011; 32: 9546-9556
3) Liu Y, Xie QR, Wang B, Shao J, Zhang T, Liu T, Huang G*, Xia W*. Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics. Protein Cell. 2013 Aug 27.
4) Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials. 2014;35:10058-10069.
5) Liu T, Zhang T, Yu H, Shen H, Xia W*. Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption. J Neuroinflammation. 2014;11:107
6) Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W*, Gao WQ*.SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Oncotarget. 2015, 6:26494-507.
7) Ji W, Yu Y, Li F, Xia W*, Lu S*. FGFR1 regulates the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway. Oncotarget. 2016, 7:15118-15134.
8) Quan Y，Xia L, Shao J, Yin S, Cheng CY, Xia W*, Gao WQ*. Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via SIRT3-ROS pathway. Scientific Reports.2015; 5:8181.
9) Yan A, Zhang T, Yang X, Shao J, Fu N, F Shen, Fu Y*, Xia W*. Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophage activation and enrichment, and ameliorates brain injury. Scientific Reports 2016,6:35885..
10) Xia W*, Geng K. A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases. Seminars in Cell & Developmental Biology 2016, 59:71-78.
11) Yang W, Zhang T, Yan A, Shao J, Liu T, Yang X, Xia W* , Fu Y*. Thromboxane A2 receptor stimulation enhances microglial interleukin-1β and NO biosynthesis mediated by the activation of ERK pathway. Frontiers Aging Neuroscience 2016,8:8.
12) Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290.Yuan H, Li ZM, Shao J, Ji WX, Xia W*, Lu S*. FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells. J Exp Clin Cancer Res. 2017; 36:72.
24. Dr. Liqin Xiong
Dr. Liqin Xiong is Special Professor of School of Biomedical Engineering, Shanghai Jiao Tong University. She received the bachelor’s degree (2004) in Chemistry and Life Science from Gannan Normal University, the master’s degree (2007) in Chemistry from Beijing Normal University, and the doctoral degree in Chemistry from Fudan University in July 2010. Dr. Xiong conducted postdoctoral research at Stanford University School of Medicine for period August 2010 to July 2012. She has published over 30 papers with a total impact factor over 140 and citation times over 2000. Dr. Xiong has won the Dow Chemical Scholarship in 2009, Fudan “Self-Dependence” Scholarship for Academic Research in 2010, Shanghai Pujiang Talent Program in 2013, and Li Lanxin Young Teacher Award in 2016.
Smart nanoprobes and tumor molecular imaging: a) Preparation of near-infrared fluorescent polymer dots for lymph node mapping, tumor-targeted imaging and cell tracking in vivo, b) Development of novel 18F-labeled rare-earth nanoprobes for multi-modal imaging, c) Development of multi-functional nanoprobes for tumor imaging and therapyin vivo.
1. Xiong L*, Guo Y, Zhang Y, Cao F, Highly luminescent and photostable near-infrared fluorescent polymer dots for long-term tumor cell tracking in vivo, J. Mater. Chem. B, 2016;4:202-6.
2. Cao X, Cao F, Xiong L*, Yang Y, Cao T, Cai X, Hai W, Li B, Guo Y, Zhang Y, Li F. Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles. Nanoscale. 2015;7(32):13404-9.
3. Xiong L*, Cao F, Cao X, Guo Y, Zhang Y, Cai X. Long-term-stable near-infrared polymer dots with ultrasmall size and narrow-band emission for imaging tumor vasculature in vivo. Bioconjug Chem. 2015;26(5):817-21.
4. Xiong L*, Shen B, Behera D, Gambhir SS, Chin FT, Rao J*. Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging. Nanoscale. 2013;5(8):3253-6.
5. Xiong L, Shuhendler AJ, Rao J*. Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging. Nat Commun. 2012;3:1193.
25. Dr. Hong Xu
Dr. Hong Xu is a professor at School of Biomedical Engineering of Shanghai Jiao Tong University. Her research interests include preparation of composite nanoparticles with precisely controllable structures and functions as well as applications of functional nanomaterials for bio-detection and clinical uses. In recent years, she has successfully transferred a number of research achievements to clinic applications, including high throughput suspension assays for multiplexed detection and high performance magnetic beads for blood screening. Dr. Xu has published over 60 peer-review papers and applied for more than 20 patents. She has received several awards including the Second Prize of Shanghai Technology Invention Award (2013), and the Second Prize of Natural Science Award of Ministry of education (2015).
(1) Preparation of composite nanoparticles with precisely controllable structures and functions.
(2) Functional nanomaterials and their interactions between bio-molecules.
(3) High performance bio-detection technology and clinical application based on micro-nano technology.
1) Ding Sheng-zi Zhang, Yang Jiang, Haiou Yang, Youjie Zhu, Shunjia Zhang, Ying Zhu,Dan Wei1, Ye Lin, PingPing Wang, Qihua Fu, Hong Xu*, Hongchen Gu*, Dual-Encoded Microbeads through a Host-Guest Structure: Enormous, Flexible and Accurate Barcodes for Multiplexed Assays, Advanced Functional Materials, 2016, 26, 6146-6157 (Cover Article)
2) Peirui Wang, Ping Xu, Pingping Wang, Lingling Deng, Hongchen Gu, Hong Xu*, Improvement of Protein Immobilization and Bioactivity of Magnetic Carriers Using a Brushed Beads-on-Beads Structure, ACS Applied Materials & Interfaces , 2015, 7, 24390?24395
3) Zhenyuan Qu, Hong Xu*, and Hongchen Gu*,Synthesis and Biomedical Applications of Poly((meth)acrylic acid) Brushes,2015, ACS Applied Materials & Interfaces,DOI: 10.1021/acsami.5b02912
4) Zhenyuan Qu, Hong Xu*, Kaimin Chen, Hongchen Gu, Ultrasensitive ELISA Using Enzyme-loaded Nanospherical Brushes as Labels, 2014, Analytical Chemistry, 86, 9367?9371
5) Zhenyuan Qu, Kaimin Chen, Hongchen Gu, Hong Xu*, Covalent Immobilization of Proteins on 3D Poly(acrylic acid) Brushes: Mechanism Study and a More Effective and Controllable Process, Bioconjugate Chemistry, 2014, 25, 370?378(Cover Article)
26.Dr. Xuemin Xu
Dr. Xu received her Ph.D. degree from University of Illinois at Urbana-Champaign, USA, in 1991. She was on the faculty of The City University of New York, and promoted to associate professor with tenure in 1996. She then moved to Purdue University and took the tenured associate professor position in Mechanical Engineering in 1997 and a joint faculty position in Biomedical Engineering in 1998. Dr. Xu became the“Chang Jiang Scholar”Distinguished Professor in Biomedical Engineering at Shanghai Jiao Tong University awarded by Chinese Ministry of Education in 2003, and received the“Outstanding Youth Award”by Chinese Natural Science Foundation (CNSF) in 2007. She was the recipient of Natural Science Award from Chinese Ministry of Education (2nd place) in 2010. Her research interests encompass fundamental study of bio-thermal physics, cancer thermal therapy, and medical device supported by NCI and NSF in US, and Chinese NSF, key national center grants from Chinese Ministry of Science and Technology. She has published more than 150 peer reviewed journal papers and conference proceedings, and four book chapters. She is an elected ASME Fellow, AIBME Fellow and a senior member of IEEE EMBS. She was the technical program chair for The 2005 EMBC in Shanghai, China and served as the AdCom Member of EMBS for 3 years since 2011. She has served as the President of Shanghai Society of Biomedical Engineering since 2010, and Deputy Secretary for International Affairs of Chinese Society of Biomedical Engineering since 2009.
(1) Xin, Y.; Zhang, A.L.; Xu, L.X.; Fowlkes, J.B.; Numerical Study of Bubble Area Evolution During Acoustic Droplet Vaporization-Enhanced HIFU Treatment, Journal of Biomechanical Engineering, 2017,139.
(2) He, K.; Liu, P.; Xu, L.X.; The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response, Cell Death & Disease, 2017, 8, 2703.
(3) Liu, K.; He, K.; Xue, T.; Liu, P.; Xu, L.X.; The cryo-thermal therapy-induced IL-6-rich acute pro-inflammatory response promoted DCs phenotypic maturation as the prerequisite to CD4+ T cell differentiation, International Journal of Hyperthermia, 2017, 6, 1.
(4) Xu, L.X.; Zhang, A.L.; Liu, P.; Thermo-immune therapy: A novel treatment for metastatic cancer, Science (special issue), 2016.
(5) Xue T.; Liu P.; Xu, L.X.; Interleukin-6 Induced“Acute”Phenotypic Microenvironment Promotes Th1 Anti-Tumor Immunity In Cryo-Thermal Therapy Revealed By Shotgun And Parallel Reaction Monitoring Proteomics; Theranostics, 2016, 6, 773.
(6) Zhu, J.; Zhang, Y.; Zhang, A.L.; He, K.; Liu, P.; Xu, L.X.; Cryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation, Scientific Reports, 2016, 6, 27136.
(7) Bai, J.F.; Liu, P.; Xu, L.X.; Recent Advances in Thermal Treatment Techniques and Thermally Induced Immune Responses Against Cancer, IEEE Transactions on Biomedical Engineering, 2014, 61, 1497.
(8) Zhu, M.L.; Jiang L.; Fabiilli M.L.; Zhang A.L.; Fowlkes J.B.; Xu L.X.; Treatment of murine tumors using acoustic droplet vaporization enhanced high intensity focused ultrasound, Physics in Medicine and Biology, 2013, 58, 6179.
27. Dr. Guo-Yuan Yang
Guo-Yuan Yang, MD/PhD, KC Wong endowed Professor of SJTU. Dr. Yang received the MD/PHD degree in 1987 in Neuroscience from Shanghai Jiao Tong University, Shanghai, China. From 1991 to 2001, he was a Research scientist in Crosby neurosurgical Lab at University of Michigan. From 2001 to 2008, he was an associate/full professor in UC San Francisco, and he was recruited by SJTU in 2008. Dr. Yang is the incumbent Associate Dean of Med-X Research Institute, and Director of the Institute of Rehabilitation Engineering at SJTU. Dr. Yang serves as the Board member of Chinese Stroke Association, Vice Chairman of the Society of Chinese Cerebrovascular and Metabolism, and the board member of more than 10 societies. Dr. Yang also serve as the Associate Editor of Stroke and Vascular Neurology, the Editor of Stroke, Frontiers in Aging Neuroscience, Aging and Disease, and the other 8 editorial board of scientific Journals. Dr. Yang was awarded NIH grants in USA, and many funds from China including NSFC, the Ministry of Science and Technology, the Ministry of Education, etc. Dr. Yang has long been engaged in neurobiology, neurology and Neurosurgery, especially cerebral vascular disease of translational research. He has published more than 250 peer reviewed papers, the h-index=61, and cited about 13000 times.
1. 1)Mechanisms of cerebral vascular disease: hemodynamics, inflammation, neurovascular unit
2. 2)Diagnosis for stroke: synchrotron radiation, optogenetics, micro-RNA, CLARITY, etc
3. 3)Therapies for stroke: drugs, genes, RNAs, proteins, stem cells
4. 4)Rehabilitation for stroke: Rehabilitation robotics, neural signal processing
5. 5)Applications of biological materials in neurological diseases
Representative publications within 5 years：
1. 1)Huang J, Song J, Qu M, Wang Y, An Q, Song Y, Yan W, Wang B, Wang X, Zhang S, Chen X, Zhao B, Liu P, Xu T, Zhang Z, Greenberg DA, Wang Y, Gao P, Zhu W, Yang GY. MicroRNA-137 and -195* inhibit vasculogenesis in brain arteriovenous malformations. Ann Neurol. 2017 Aug 12. doi: 10.1002/ana.25015. [Epub ahead of print]
2. 2)Ma Y, Wang J, Wang Y, Yang GY. The biphasic function of microglia in ischemic stroke. Prog Neurobiol. 2016 Feb 2. [Epub ahead of print] Review.
3. 3)Tang Y, Zhang C, Wang J, Lin X, Zhang L, Yang Y, Wang Y, Zhang Z, Bulte JW, Yang GY. MRI/SPECT/Fluorescent Tri-Modal Probe for Evaluating the Homing and Therapeutic Efficacy of Transplanted Mesenchymal Stem Cells in a Rat Ischemic Stroke Model. Adv Funct Mater. 2015;25(7):1024-1034.
4. 4)Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, Yang GY. Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia. Stem Cells. 2014 Dec;32(12):3150-62. doi: 10.1002/stem.1808.
5. 5)Zeng L, Liu J, Wang Y, Wang L, Weng S, Chen S, Yang GY. Cocktail blood biomarkers: prediction of clinical outcomes in patients with acute ischemic stroke. Eur Neurol. 2013;69(2):68-75. doi: 10.1159/000342896. Epub 2012 Nov 14.
28. Dr. Jian Ye
Dr. Jian Ye received the B.E. degree in 2000 and the M.S. degree in 2003 in polymer science and engineering from Zhejiang University, Zhejiang, China, and the Ph.D. degree in 2010 in chemistry from Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium. From 2003 to 2005, he was at Intel Products (Shanghai) Ltd. as a Material Engineer. From 2005 to 2010, he performed the Ph.D. research project in Interuniversity Microelectronics Centre (IMEC) vzw, Belgium. Since 2010, he has been a Postdoctoral Fellow of the Research Foundation–Flanders (FWO), KU Leuven. In 2011 (March–September), he was with the nanophotonics group of Prof. Naomi Halas at Rice University as a Visiting Scholar. He joined the School of Biomedical Engineering of Shanghai Jiao Tong University as the Professor of Special Appointment in 2013. He has been involved in a number of industrial and European research projects and has authored or coauthored 52 referred papers, 1 book chapter, and 9 patents. Dr. Ye has received a number of awards including Scholar of “Thousand Talent Program for Young Outstanding Scientists” from the Chinese Government (2013), and Outstanding Youth Fund from Chinese National Natural Science Foundation (2016).
(1) Design, fabrications, and optical properties of plasmonic nanomaterials including Finite Difference Time Domain (FDTD) simulations, wet chemistry and physical lithographic fabrications, near-field and far-field characterizations.
(2) Biomedical applications of plasmonic nanomaterials including highly sensitive and multiplexed molecular diagnostic methods, nanomaterials-based biomedical imaging and therapy.
(3) Surface-enhanced Raman spectroscopy (SERS) including substrate design and fabrications, enhancement mechanism, and SERS-based molecular diagnostic and intraoperative tumor imaging.
(1) Lin, L. #; Zapata, M. #; Xiong, M.; Liu, Z.; Wang, S.; Xu, H.; Borisov, A. G.; Gu, H.; Nordlander P.*; Aizpurua, J.*; Ye, J.*; Nanooptics of plasmonic nanomatryoshkas: shrinking the size of a core-shell junction to subnanometer, Nano Letters, 2015, 15, 6419.
(2) Lin, L.; Gu, H.*; Ye, J.*; Plasmonic multi-shell nanomatryoshka particles as highly tunable SERS tags with built-in reporters, Chemical Communications, 2015, 51, 17740.
(3) Wen, F.F.#; Ye, J.*,#; Liu, N.#; Van Dorpe, P.; Nordlander, P.; Halas, N.J.* Plasmon Transmutation: Inducing New Modes in Nanoclusters by Addling Dielectric Nanoparticles, Nano Letters, 2012, 12, 5020. (#: equal contribution)
(4) Ye, J.*,#; Wen, F. #; Sohbani, H.; Lassiter, B.; Van Dorpe, P.; Nordlander, P.; Halas, N.* Plasmonicnanoclusters: near field properties of the Fano resonance interrogated with SERS, Nano Letters, 2012, 12, 1660. (#: equal contribution)
(5) Ye, J.*; Verellen, N.; Van Roy, W.; Lagae, L.; Maes, G.; Borghs, G.; Van Dorpe, P. Plasmonic modes of metallic semishells in a polymer film, ACS Nano, 2010, 4, 1457.
29. Dr. Chunfu Zhang
Dr. Chunfu Zhang obtained his Ph. D. degree in 2002 from Chinese Academy of Sciences (ACS). During the next two years, he became Assistant Professor/Associate Professor in Shanghai Institute of Applied Physics, CAS. At the end of 2004, he moved to Germany and joined Professor Fabian Kiessling group in German Cancer Research Center (DKFZ) as a guest scientist. In June 2007, he moved to USA and conducted research in Professor Jinming Gao group in UT Southwestern Medical Center. He joined the Med-X Research Institute, Shanghai Jiao Tong University in 2008. Currently he is Professor in School of Biomedical Engineering, SJTU. He has published two book chapters and 55 peer-reviewed papers, including Cancer Research, Biomaterials, Radiology, Advanced Functional Materials, ACS Nano and Nanoscale.
(1) Design and prepare multifunctional nano probes for image-guided cancer therapy. The imaging modalities include nuclear imaging, MRI, fluorescent imaging, photoacoustic imaging or combinations of them. The therapeutic modalities include chemo, photothermal, radiation, photodynamic therapies or combinations of them.
(2) Multifunctional nanoprobes for stem cell tracking.
1. Lu Zhang, Huilan Su, Jiali Cai, Dengfeng Cheng, Yongjie Ma, Jianping Zhang, Chuanqing Zhou, Shiyuan Liu, Hongcheng Shi, Yingjian Zhang, and Chunfu Zhang*. A Multifunctional Platform for Tumor Angiogenesis-Targeted Chemo-Thermal Therapy Using Polydopamine-Coated Gold Nanorods. ACS Nano 2016, 10, 10404?10417.
2. Yi Yang, Lu Zhang, Jiali Cai, Xiao Li, Dengfeng Cheng, Huilan Su, Jianping Zhang, Shiyuan Liu, Hongcheng Shi, Yingjian Zhang, Chunfu Zhang*. Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging. ACS Appl. Mater. Interfaces 2016, 8, 1718?1732.
3. Yaohui Tang, Chunfu Zhang,* Jixian Wang, Xiaojie Lin, Lu Zhang, Yi Yang, Yongting Wang, Zhijun Zhang, Jeff W. M. Bulte, and Guo-Yuan Yang*. MRI/SPECT/Fluorescent Tri-Modal Probe for Evaluating the Homing and Therapeutic Effi cacy of Transplanted Mesenchymal Stem Cells in a Rat Ischemic Stroke Model. Adv. Funct. Mater. 2015, 25, 1024–1034.
4. Q. Li, G. Tang, S. Xue, X. He, P. Miao, Y. Li, J. Wang, L. Xiong, Y. Wang, C. Zhang,* G.-Y. Yang*. Silica-coated superparamagnetic iron oxide nanoparticles targeting of EPCs in ischemic brain injury, Biomaterials, 2013, 34, 4982-4992.
5. L. Zhang, Y. Wang, Y. Tang, Z. Jiao, C. Xie, H. Zhang, P. Gu, X. Wei, G.-Y. Yang, H.Gu, C. Zhang*. High MRI performance fluorescent mesoporous silica-coatedmagnetic nanoparticles for tracking neural progenitor cells in an ischemic mouse model. Nanoscale, 2013, 5, 4506–4516.
30. Dr. Pu-Ming Zhang
Dr. Pu-Ming Zhang received her bachelor's degree of Automation in Industry from Zhejiang University in 1997, and Ph.D. degree of Control Science and Engineering from Zhejiang University in 2002. She conducted post-doctoral research at Shanghai Jiao Tong University (2002-2003) before joining Department of Biomedical Engineering, SJTU in 2004 as an Associate Professor. Dr. Zhang is supported by many research agencies including the NSFC.
Neural Information Processing: Epileptiform discharges in key brain regions in vitro and in vivo, and clinical data analysis
(1) Li YH, Li JJ, Lu QC, Gong HQ, Liang PJ, Zhang PM*. Involvement of thalamus in initiation of epileptic seizures induced by pilocarpine in mice. Neural Plasticity. 2014, doi:10.1155/2014/675128.
(2) Li JJ, Li YH, Gong HQ, Liang PJ, Zhang PM*, Lu QC*. The spatiotemporal dynamics of phase synchronization during epileptogenesis in amygdala-kindling mice. PLoS One, 2016, 11(4): e0153897.
(3) Mao JW, Ye XL, Li YH, Liang PJ, Xu JW*, Zhang PM*. Dynamic network connectivity analysis to identify the epileptogenic zones based on stereo-electroencephalography. Frontiers in Computational Neuroscience, 2016, 10:113.
(4) Li YH, Ye XL, Liu QQ, Mao JW, Liang PJ, Xu JW, Zhang PM*. Localization of epileptogenic zone based on graph analysis of stereo-EEG. Epilepsy Research, 2016，128: 149-157.
31. Dr. Shiyi Zhang
Dr. Shiyi Zhang has been an assistant professor in the School of Biomedical Engineering at the Shanghai Jiao Tong University since 2016. He obtained his bachelor’s degree from Peking University in Beijing in 2008. After then, he started his Ph.D. study with Prof. Karen Wooley at the Washington University in St. Louis. His PhD research interests ranged from degradable polymer for nanomedicine to the polymer self-assembly for functional nanostructures. Upon the completion of his PhD research in 2013, he arrived at MIT as a Max-Planck Postdoctoral Fellow with Prof. Robert S. Langer, focusing the translational study for gastrointestinal drug delivery. Dr. Zhang’s research appears in more than thirty-one articles in leading chemistry and polymer journals, including Nature Materials, Science Translational Medicine, Journal of the American Chemical Society, ACS Nano, Advanced Materials, Advanced Functional Materials, Macromolecules and ACS Macro Letters, and results six US and international patents. He also helped to build the biotech startup, Lyndra, to push the gastric retentive drug delivery system into clinic. Dr. Zhang received 1000 Plan Program for Young Talents in 2015.
Current research interests: therapeutic treatments of adverse effects caused by targeted therapies, polymeric materials for the management of blood glucose spikes after meals, synthetic small blood vessels for cardiac bypass surgery.
1. Bellinger, A. M.*; Jafari, M.*; Grant, T. M.*; Zhang, S. *; Slater, H.; Wenger, E.; Mo, S.; Lee, Y-A. L.; Mazdiyasni, H.; Kogan, L.; Barman, R.; Cleveland, C.; Booth, L.; Bensel, T.; Minahan, D.; Hurowitz, H. M.; Tai, T.; Daily, J.; Nikolic, B.; Wood, L.; Eckhoff, P.; Langer, R.; Traverso, G. "Oral Ultra Long-Acting Drug Delivery: Single Encounter Ivermectin for Malaria Eradication" Sci. Transl. Med. 2016, 8, 365ra157. (* equal contribution)
2. Zhang, S.; Bellinger, A. M.; Glettig, D. L.; Barman, R.; Lee, Y.-A. L.; Zhu, J.; Cleveland, C.; Montgomery, V. A.; Gu, Li, Nash, L. D.; Maitland, D. J.; Langer, R.; Traverso G. "A pH-responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices" Nat. Mater., 2015, 14, 1065.
3. Zhang, S.*; Zou, J.*; Elsabahy M.; Karwa, A.; Li, A.; Moore, D. A.; Dorshow, R. B.; Wooley, K. L. "Poly(ethylene oxide)-block-polyphosphester-based Paclitaxel Conjugates as a Platform for Ultra-high Paclitaxel-loaded Multifunctional Nanoparticles", Chem. Sci., 2013, 4, 2122. (* equal contribution)
4. Zhang, S.; Zou, J.; Zhang, F.; Elsabahy M.; Felder, S.; Zhu, J.; Pochan, D. J.; Wooley, K. L. "Rapid and Versatile Construction of Diverse and Functional Nanostructures Derived from a Polyphosphoester-based Biomimetic Block Copolymer System", J. Am. Chem. Soc., 2012, 134, 18467.
5. Zhang, S.; Li, Z.; Samarajeewa, S.; Sun, G.; Yang, C.; Wooley, K. L. "Orthogonally Dual Clickable Janus Nanoparticles via a Cyclic Templating Strategy", J. Am. Chem. Soc., 2011, 133, 11046.
32. Dr. Yan Zhang
Dr. Yan Zhang received M.D. degree from Shandong Medical University in 1999, Ph.D. degree from Shandong University in 2005 and conducted post-doctoral research at NYU from 2005 to 2007, at Weill Cornell Medical College from 2007 to 2012. She now is the Professor of Special Appointment at Shanghai Jiaotong University. She studied on the differentiation and polarization of tumor-associated immune cells, find out the abnormal immune cells in patients with tumors and figure out the molecular mechanism on their formation. Since 2005, she has published 14 SCI papers, which has a total SCI score of more than 100. Now she undertakes two grants from NSFC and one grant from SJTU.
(1) Explore the mechanism on the abnormal differentiation and polarization of tumor-associated immune cells
(2) Find out the effects of biomaterials and nanoparticles on the differentiation and polarization of tumor-associated immune cells.
(1) Zhang Y#, Luo Y#, Qin SL, Mu YF, Yu MH, Zhong M. The Clinical impact of ICOS signal in colorectal cancer patients. Oncoimmunology, 2016, 5(5): e1141857 (#, co-first author)
(2) Zhang QF, Qin JL, Zhong L, Gong L, Zhang B, Zhang Y* and Gao WQ*. CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer. Cancer Research. 2015, 75(20):4312-4321 (*, co-corresponding authors)
(3) Zhang Y, Lv D, Kim HJ, Kurt RA, Bu W, Li Y and Ma X. A Novel Role of Hematopoietic CCL5 in Promoting Triple-negative Mammary Tumor Progression by Regulating Generation of Myeloid-derived Suppressor Cells. Cell Research, 2013, 23:(3)394-408
(4) Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY and Liu CJ. The Growth Factor Progrannulin Binds to TNF Receptor and Is Therapeutic Against Inflammatory Arthritis in Mice. Science. 2011;332:(6028)478-484
(5) Zhang Y and Ma X. Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-bingding protein alpha. J Immunol. 2010;184:(7)3866-3877
(6) Zhang Y, Kim HJ, Yamamoto S, Kang X and Ma X. Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells (Review). J Interferon Cytokine Res. 2010;30:(3)113-122
(7) Zhang Y, Kong Li, Carlson CS and Liu CJ. Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation. Cell Death Differ. 2008;15:(11)1760-1771
(8) Zhang Y, Howell RD, Alfonso DT, Yu J, Kong L, Wittig JC and Liu CJ. IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. Front Biosci. 2007;12:(4)4855-4863
33. Dr. Jun Zhao
Dr. Jun Zhao received his Ph.D. in Biomedical Engineering from Shanghai Jiao Tong University, Shanghai, China in 2006. Dr. Zhao is a full Professor and the Associate Dean of School of Biomedical Engineering at Shanghai Jiao Tong University. He was a visit scholar at University of Iowa, USA, in 2006-2007.
His research interests include CT reconstruction, medical imaging, medical image processing, computer-aided detection and medical applications of synchrotron radiation. Dr. Zhao received over 10 grants from Ministry of Science and Technology of China, National Science Foundation of China (NSFC), Science and Technology Commission, Education Commission of Shanghai Municipality, GE and etc. He with his coauthors published over 100 journal articles and conference papers, including the first paper on exact triple-source cone-beam CT, the first paper on virtual eversion of colon. He has over 20 patents. He is recognized by a number of awards for academic and educational achievements. He serves as an associate editor for Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, and International Journal of Biomedical Imaging. He is also active in the international research groups of, IEEE EMBC, SPIE and ISBI.
(1) CT reconstruction, MRI reconstruction, medical imaging.
(2) Computer-aided detection for lesions (lung nodules, colon polyps), medical image processing and analysis.
(3) Medical applications of synchrotron radiation.
(1) Xi Y, Chen Y, Tang R, Sun J, Zhao J*, United iterative reconstruction for spectral computed tomography, IEEE Trans. Medical Imaging, Vol.34,769-778, 2015.
(2) Song Y, Zhu Z, Zhao J*, Reconstruction of magnetic resonance imaging by dual-dictionary learning, Magnetic Resonance in Medicine, 71(3):1285-1298 2014.
(3) Xi, Yan, and Jun Zhao*. "Inner-focusing reconstruction method for grating-based phase-contrast CT." Optics Express, 21.5 (2013): 6224-6232.
(4) Lu Y, Zhao J*, and Wang G, Few-view image reconstruction with dual dictionaries, Phys. Med. Biol., 2012; 57:173-189
(5) Zhang D, Zhao J*, Lu L, Li L, and Wang Z, Virtual eversion and rotation of colon based on outer surface centerline, Medical Physics, 2010; 37:5518-5529
(6) Xi Y, Rong T, Wang Y, and Zhao J*, Microbubbles as agent for in-line x-ray phase-contrast imaging, Applied Physics Letter, 2011; 99:011101
(7) Zhao J*, Jin Y, Lu Y, and Wang G, A filtered backprojection algorithm for triple-source helical cone-beam CT,IEEE Trans. Medical Imaging, 2010; 29:756-770
(8) Lu Y, Zhao J*, and Wang G, Exact image reconstruction with triple-source saddle-curve cone-beam scanning, Phys. Med. Biol., 2009; 54:2971-2991
34. Dr. Xiaodong Zhao
Dr. Xiaodong Zhao received the B.S. degree in 1995 and the M.S. degree in 2000 in Wuhan Institute of Virology, Chinese Academy of Science, and the Ph.D. degree in 2003 in China Centre of Disease Control and Prevention, Beijing, China. Since the end of 2003, he has been a postdoctoral fellow of Genome Institute of Singapore. In 2008, he was employed as a research associate in Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK. He joined Shanghai Jiao Tong University as the Professor of Special Appointment in 2010. He has been involved in ENCODE project with the efforts to develop and apply cutting-edge high throughput genomic technologies to explore genome function. He has authored or coauthored 32 referred papers with the citation over 5000.
(1) Epigenetics in stem cells To understand how epigenetic regulation contributes to specifying stem cell identity through integrative epigenetic profiling of various kinds of histone modifications and DNA methylation.
(2) Transcriptional network in tumor cells To understand how transcription factors regulate their target genes and the their implications in tumor initiation and development by using various genomics approaches.
(1) Zhang XL, Wu J, Wang J, Shen T, Li H, Lu J, Gu Y, Kang Y, Wong CH, Ngan CY, Shao Z, Wu J, Zhao X*. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol. 2016;17(1):162.
(2) Lu J, Chen J, Xu N, Wu J, Kang Y, Shen T, Kong H, Ma C, Cheng M, Shao Z, Xu L, Zhao X*. Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016;258:227-36.
(3) Qi Y, Ooi HS, Wu J, Chen J, Zhang X, Tan S, Yu Q, Li YY, Kang Y, Li H, Xiong Z, Zhu T, Liu B, Shao Z, Zhao X*. MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10. Oncotarget. 2016;7(11):12693-703.
(4) Lai DP, Tan S, Kang YN, Wu J, Ooi HS, Chen J, Shen TT, Qi Y, Zhang X, Guo Y, Zhu T, Liu B, Shao Z, Zhao X*. Genome-wide profiling of polyadenylation sites reveals a link between selective polyadenylation and cancer metastasis. Hum Mol Genet. 2015; 24(12): 3410-7.
(5) Qi Y, Zhang X, Kang Y, Wu J, Chen J, Li H, Guo Y, Liu B, Shao Z, Zhao X*. Genome-wide transcriptional profiling analysis reveals annexin A6 as a novel EZH2 target gene involving gastric cellular proliferation. Mol Biosyst. 2015; 11(7):1925-32.
35. Dr. Chuanqing Zhou
Dr. Chuanqing Zhou, received his Ph.D. degree in Biomedical Engineering from Shanghai Jiao Tong University in 2007. Currently he is the Associate Professor of Shanghai Jiao Tong University School of Biomedical Engineering. He has been mainly engaged in the studies of biomedical optical imaging, novel ophthalmic technologies and instrumentations. He has published more than 60 papers in the peer reviewed journals and 2 book chapters, and held 6 patents in the field of optical imaging and ophthalmology. He has developed and industrialized several ophthalmic instruments, including slit-lamp microscope integrated optical coherence tomography, multimodal optical coherence tomography, and multi-wavelength laser retinal coagulator. In the past 5 years, he has been the PIs and key investigators of 12 research projects supported by National Science Foundation of China (NSFC), Ministry of Science and Technology (MOST), Ministry of Education (MOE), and Science and Technology Commission of Shanghai Municipality (STCSM), respectively.
(1) Multimodal imaging of optical coherence tomography, photoacoustic microscopy, and confocal fluorescent imaging
(2) Applications of multimodal imaging and laser treatment in eye diseases
(3) Development of novel ophthalmic instruments
(1) Li Q, Li L, Yu T, Zhao Q, Zhou C*, Chai X*. Vascular tree extraction for photoacoustic microscopy and imaging of cat primary visual cortex. Journal of Biophotonics. 2017; 10: 780-791
(2) Li L, Dai C, Li Q, Zhao Q, Jiang X, Chai X*, Zhou C*. Fast subcellular optical coherence photoacoustic microscopy for pigment cell imaging. Optics Letters. 2015; 40(19): 4448-4451
(3) Fan S, Li L, Li Q, Dai C, Ren Q, Jiao S*, Zhou C*. Dual band dual focus optical coherence tomography for imaging the whole eye segment. Biomedical Optics Express. 2015; 6(7): 2481-2493
(4) Han Z, Tao C, Zhou D, Sun Y, Zhou C*, Ren Q, Roberts C. Air puff induced corneal vibration: theoretical simulations and clinical observations. Journal of Refractive Surgery. 2014; 30(3): 208-213
(5) Luo T, Huang P, Gao G, Shen G, Fu S, Cui D, Zhou C*, and Ren Q*. Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging. Optics Express. 2011; 19: 17030-17039