Weiliang Xia

Weiliang Xia, Ph.D., is currently Professor at School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University. Dr. Xia obtained his doctoral degree from the University of Hong Kong in 2006, with predoctoral training at the Rockefeller University, followed by postdoctoral fellowship at University of California, San Francisco from 2007 to 2008. Dr. Xia has published 100 papers or book chapters since 2005, which have been cited over 5000 times. He has been awarded the Rising Star Prize by Shanghai Science and Technology Commission, and is funded by National Natural Science Foundation of China and Ministry of Science and Technology. 

The main research topics in his group include molecular mechanisms of cancer progression and cancer therapy by using multidisciplinary approaches; brain ischemia protection and tissue repair; functional studies on Sirtuin family proteins.

1. Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W*.NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation Protein Cell (accepted) 

2. Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AST, Sha J*, Xia W*. Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer. Theranostics. 2021;11:6526-6541.

3. Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*. Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. Oncogene. 2020; 37:3507–3521.

4. Li F, Li X, Li Z, Ji W, Lu S, Xia W*. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019; 9:7474-7489.

5. Yan L, Li H*, Xia W*. Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity. Cell Prolif. 2020;53: e12906.

6. Cheng Y, Zeng Q, Han Q, Xia W*. Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell. 2019; 10:295-299.

7. Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W*, Gao WQ*. Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ.2019; 26:2479-2492.

8. Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*.FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. Oncogene. 2018;37:5340-5354.

9. Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*. The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer. Cancer Lett. 2018; 423:36-46.

10. Yang X, Geng K, Zhang Y, Zhang J, Shao J, Xia W*. Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. CNS Neurosci Ther.2018;24:775-783.

11. Zhang T, Yang X, Liu T, Shao J, Fu N, Yan A, Geng K, Xia W*.Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice. Stem Cell Res Ther. 2017, 8:248.

12. Yang X, Geng K, Zhang J, Zhang Y, Shao J, Xia W*. Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. Front Pharmacol. 2017 Dec 22;8:943.

13. Xia W*, Geng K. A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases. Semin Cell Dev Biol.2016;59:71-78.

14. Shao J, Yang X, Liu T,Zhang T,Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290.  

15. Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier.Biomaterials. 2014;35:10058-10069. 




address:教三楼 211室