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Yan Zhang Associate Professor (Special Research Fellow) and Doctoral Supervisor. Holds a Bachelor of Medicine from Shandong Medical University, a Ph.D. from Shandong University, and completed postdoctoral training at New York University and Cornell University, USA. Has published nearly 20 SCI papers as first or corresponding author in prestigious international journals including Cell Research, Circulation, Advanced Science, Cancer Research, Cancer Letters, Oncoimmunology, and Clinical and Translational Medicine, with a cumulative impact factor exceeding 200. Currently serves as Principal Investigator for 7 national-level research projects (including the Key R&D Program, NSFC General Program, and NSFC Young Scientists Fund) and 6 provincial/ministerial-level projects. Holds editorial positions as Editor of Global Medical Genetics and serves as ad hoc reviewer for Frontiers in Cell and Developmental Biology, Cancer Management and Research, and Translational Oncology. Regularly invited to review grants for the National Natural Science Foundation of China and manuscripts for multiple scientific journals. |
Intelligent Immunology: Mechanistic Studies on Differentiation and Polarization of Disease-Associated Immune Cells; AI+Immunology
Immune Engineering: Synthetic Immunology Research for Cell Therapy
1. Zhang Y*, Wang ZE, Lu Y, Sanchez J.D, Li JJ, Wang LH, Meng XX, Zhong M*, Gao WQ*, Ding XT*. Region-specific CD16+ neutrophils promote colorectal cancer progression by inhibiting natural killer cells, Advanced Science, 2024, 11(29):e2403414 (IF=15.1)
2. Lin HP, Luo Y, Gong TY, Fang HS, Li H, Ye GY, Zhang Y*, Zhong M*. GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer, Cell Oncolgoy, 2024, 47(4):1149 (IF=4.9)
3. Qu JW, Li DW, Jin JS, Sun N, Wu JJ, Zhang Y*, Yuan XD*, Zhang M*. Hypoxia-Inducible Factor 2a Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Mode Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice, J Am Soc Nephrol, 2023, 34(1):73 (IF=8.65)
4. Wang C, Zhang Y*, Gao WQ*. The involving role of immune cells in prostate cancer, Cancer Letters, 2022, 252:9-12 (IF=9.7)
5. Fang HS#，Huang YZ#，Luo Yang # ，Tang JY，Yu MH，Zhang Y*，Zhong M*, SIRT1 induces the accumulation of TAMs at colorectal cancer tumor sites via the CXCR4/CXCL12 axis. Cell Immunology, 2022, 371:104458 (IF=4.868)
6. Xu YJ#, Chen JJ#, Huang YZ, Luo Y, Hsieh AC, Li H, Wei XB*, Gao WQ*, Zhong M*, Zhang Y*. Patient-derived organoids in cellulosic sponge model chemotherapy response of metastatic colorectal cancer, Clin Transl Med, 2021, 11(1):e285 (IF=11.492)
7. Fang HS#，Huang YZ#，Luo Yang # ，Tang JY，Yu MH，Zhang Y*，Zhong M*, SIRT1 induces the accumulation of TAMs at colorectal cancer tumor sites via the CXCR4/CXCL12 axis. Cell Immunology, 2022, 371:104458 (IF=4.868)
8. Lu Y #, Huang YZ #, Huang Lei #, Xu YJ, Wang ZE, Li H, Zhang T, Zhong M*, Gao WQ*, Zhang Y*. CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients, BMC Immunology, 2020, 21;46 (IF=3.615)
9. Wang Chao; Chen Jiahuan; Zhang Qianfei; Li Wang; Zhang Shengbo; Xu Yanjie; Wang Fang; Zhang Bing; Zhang Yan*; Gao Wei-qiang*; Elimination of CD4lowHLA-G+ T cells overcomes castrationresistance in prostate cancer therapy, Cell Research, 2018, 28(11): 1103-1117 (IF=11.615)
E-mail：yanzh@sjtu.edu.cn
address：教三楼 308
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