School of biomedical engineering, Shanghai jiaotong university

shenfeng

Dr. Feng Shen is a tenure associate professor in School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University. Dr. Shen received his Ph.D. degree from the University of Chicago. After graduation, he continued worked at the University of Chicago as Postdoc researcher. In 2011, he co-founded SlipChip Corporation to commercialize SlipChip technology, which he co-invented previously. In company, he served as director of research and development and PI/co-PI for grants from NIH. His work has been published on JACS, Analytical Chemistry, Lab on a Chip, PNAS, etc. He has a broad interest in new microfluidic platforms for diagnostics and life science research, including but not limited to, digital nucleic acid amplification, single cell analysis, liquid biopsy, cancer immunotherapy, integrated point-of-care systems.

Education

2001-2005 Tsinghua University, Chemistry

2005-2010 University of Chicago, Chemistry

Work experience

2011-2017 Talis Biomedical Cooperation Founder/Director of R&D/Director of Product Development

2018-2023 Shanghai Jiao Tong University, School of Biomedical Engineering, Associate Professor

2014-present Shanghai Jiao Tong University, School of Biomedical Engineering, Associate Professor (Tenured)

Research

The main research directions are new microfluidic chips for biological research and clinical diagnosis, including but not limited to:

Single molecule gene test; Liquid biopsy; Small integrated genetic analysis system; High-throughput single-cell analysis; Lab on a chip; Combine applications with related nanomaterials and other directions.

Monograph

39. Yang Luo, Qixin Hu, Yan Yu, Weiyuan Lyu, Feng Shen* Experimental Investigation of Confinement Effect in Single Molecule Amplification via Real-time Digital PCR on a Multivolume SlipChip, Analytica Chimica Acta, in press

38. Jiajie Zhang, Lei Xu, Zheyi Sheng, Jiayi Zheng, Weiyu Chen, Qixin Hu, Feng Shen* Combination-lock SlipChip Integrating Nucleic Acid Sample Preparation and Isothermal LAMP Amplification for the Detection of SARS-CoV-2, ACS Sensors, 2024, 9, 2, 646-653(Cover Issue)

37. Yan Yu, Sheng Wang, Yang Luo, Chang Gu, Xin Shi,* Feng Shen,* Quantitative Investigation of Methylation Heterogeneity by Digital Melting Curve Analysis on a SlipChip for Atrial Fibrillation. ACS Sensors, 2023, 8, 9, 3595–3603

36. Weiyuan Lyu, Jingwei Yi, Qingsheng Guo, Yao Wang, Jiajie Zhang, Tong Sun, Haoji Ma, Tingting Tang, Xueling Quan, Hong Xu,* Feng Shen,* Hongchen Gu Multiplex Digital Immunoassays with Reduced Pre-partition Reaction via Massively Parallel Reagent Delivery on a Bead-based SlipChip. ACS Nano, 2023, 17, 13, 12641–12651

35. Xiang Li, Qixin Hu, Xu Liu, Jianfang Liu, Nannan Wu, Feng Shen* Rapid Bacteriophage Quantification by Digital Biosensing on a Slip-Chip Microfluidic Device. Analytical Chemistry, 2023, 95, 22, 8632–8639

34. Qixin Hu,# Fariha Kanwal,# Weiyuan Lyu, Jiajie Zhang, Xu Liu, Kai Qin,* Feng Shen* Multiplex Digital PCR on a Droplet Array SlipChip for Analysis of KRAS Mutations in Pancreatic Cancer. ACS Sensors, 2023, 8, 114-121

33. Xiang Li, Xu Liu, Ziqing Yu, Yang Luo, Qixin Hu, Zhenye Xu, Jia Dai, Nannan Wu,* Feng Shen* Combinatorial Screening SlipChip for Rapid Phenotypic Antimicrobial Susceptibility Testing. Lab on a Chip, 2022, 22, 3952-3960

32. Xu Liu, Xiang Li, Nannan Wu, Yang Luo, Jiajie Zhang, Ziqing Yu, Feng Shen* Formation and Parallel Manipulation of Gradient Droplets on a Self-partitioning SlipChip for Phenotypic Antimicrobial Susceptibility Testing. ACS Sensors, 2022, 7, 1977-1984 (Cover Issue)

31. Ziqing Yu,# Lei Xu,# Weiyuan Lyu, Feng Shen* Parallel Multistep Digital Analysis SlipChip Demonstrated with the Quantification of Nucleic Acid by Digital LAMP-CRISPR. Lab on a Chip, 2022, 22, 2954-2961 (Cover Issue)

30. Jin Li,# Chang He,# Haijun Qu,# Feng Shen,* Jian Ye* Five-dimensional unclonable anticounterfeiting orthogonal Raman Labels. Journal of Materials Chemistry C, 2022, 10, 7273-7282

29. Jin Li, Fugang Liu, Chang He, Feng Shen, Jian Ye* Orthogonal gap-enhanced Raman tags for interference-free and ultrastable surface-enhanced Raman scattering. Nanophotonics, 2022, 0689

28. Yan Yu, Ziqing Yu, Xufeng Pan, Lei Xu, Rui Guo, Xiaohua Qian, Feng Shen*, Multiplex Digital PCR with Digital Melting Curve Analysis on a Self-partitioning SlipChip. Analyst, 2022, 147, 625-633

27. Weiyuan Lyu, Jiajie Zhang, Yan Yu, Lei Xu, Feng Shen*, Slip Formation of a High-Density Droplet Array for Nucleic Acid Quantification by Digital LAMP with a Random-Access System. Lab on a Chip, 2021, 21, 3086-3093

26. Chang Gu, Shi Xin, Wenli Qiu, Zhenyu Huang, Yan Yu, Feng Shen*, Yumei Chen*, Xufeng Pan*, Comprehensive analysis of the prognostic role and mutational characteristics of m6A related genes in lung squamous cell carcinoma. Front. Cell Dev. Biol. 2021, 9, 661792

25. Lei Xu,# Haijun Qu,# Daniel Garcia Alonso, Ziqing Yu, Yan Yu, Yejing Shi, Chunlan Hu, Tongyu Zhu, Nannan Wu,* Feng Shen*，Portable Integrated Digital PCR System for the Point-of-Care Quantification of BK Virus from Urine Samples. Biosensors and Bioelectronics 2021, 175, 112908

24. Chang Gu，Xin Shi，Chenyang Dai，Feng Shen，Gaetano Rocco，Jiafei Chen，Zhengyu Huang，Chunji Chen，Chuan He，Tao Huang，Chang Chen*, RNA m6 A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications. The Innovation Volume 1, Issue 3, 25 November 2020, 100066

23. Ziqing Yu,# Weiyuan Lyu,# Mengchao Yu,# Qian Wang,# Haijun Qu, Rustem F. Ismagilov, Xu Han, Dongmei Lai,* Feng Shen*, Self-partitioning SlipChip for Slip-induced Droplet Formation and Human Papillomavirus Viral Load Quantification with Digital LAMP. Biosensors and Bioelectronics 2020, 155 (2020) 112107

22. Haijun Qu, Mengchao Yu, Wenbin Du, Lei Xu, Weiyuan Lyu, Feng Shen, Slip Molding for Precision Fabrication of Microparts. Langmuir 2020, 36, 585-590 (Cover Issue)

21. Weiyuan Lyu, Mengchao Yu, Haijun Qu, Ziqing Yu, Wenbin Du, Feng Shen, Slip-driven Microfluidic Devices for Nucleic Acid Analysis. Biomicrofluidics 2019, 4,041502

20. Mengchao Yu, Xiaoying Chen, Haijun Qu, Liang Ma, Lei Xu, Weiyuan Lv, Hua Wang, Rustem F. Ismagilov, Min Li*, Feng Shen*, Multistep SlipChip for the Generation of Serial Dilution Nanoliter Arrays and Hepatitis B Viral Load Quantification by Digital Loop Mediated Isothermal Amplification. Analytical Chemistry 2019, 91, 14, 8751-8755 (Cover issue)

19. García Alonso, D.; Yu, M.; Qu, H.; Ma, L.; Shen, F. Advances in Microfluidics-Based Technologies for Single Cell Culture. Advanced Biosystems 2019, 1900003, 1–10

18. Nie, M.; Zheng, M.; Li, C.; Shen, F.; Liu, M.; Luo, H.; Song, X.; Lan, Y.; Pan, J. Z.; Du, W. Assembled Step Emulsification Device for Multiplex Droplet Digital Polymerase Chain Reaction. Analytical Chemistry 2019, 91 (3), 1779–1784

17. Feng Shen, Methods in Molecular Biology 2016

16. Stefano Begolo, Feng Shen, and Rustem F. Ismagilov, Lab Chip 2013 13: 4331-4342 (Cover issue)

15. Bing Sun, Feng Shen, Stephanie E. McCalla, Jason E. Kreutz, Mikhail A. Karymov, and Rustem F. Ismagilov, Analytical Chemistry 2013 85: 1540-1546

14. Feng Shen, Bing Sun, Jason E. Kreutz, Elena K. Davydova, Wenbin Du, Poluru L. Reddy, Loren J. Joseph, and Rustem F. Ismagilov, Journal of the American Chemical Society 2011 133: 17705-17712

13. Jason E. Kreutz, Todd Munson, Toan Huynh, Feng Shen, Wenbin Du, and Rustem F. Ismagilov, Analytical Chemistry 2011 83: 8158-8168

12. Feng Shen, Elena K. Davydova, Wenbin Du, Jason E. Kreutz, Olaf Piepenburg, and Rustem F. Ismagilov, Analytical Chemistry 2011 83:3533-3540

11. Feng Shen, Wenbin Du, Jason E. Kreutz, Alice Fok, and Rustem F. Ismagilov, Lab Chip 2010 10: 2666-2672 (Cover issue)

10. Feng Shen, Wenbin Du, Elena K. Davydova, Mikhail A. Karymov, Janmajay Pandey, and Rustem F. Ismagilov, Analytical Chemistry 2010 82:4606-4612

9. Feng Shen, Rebecca R. Pompano, Christian J. Kastrup, and Rustem F. Ismagilov, Biophysical Journal 2009 97: 2137-2145

8. Christian J. Kastrup, James Q. Boedicker, Andrei P. Pomerantsev, Mahtab Moayeri, Yao Bian, Rebecca R. Pompano, Timothy R. Kline, Patricia Sylvestre, Feng Shen, Stephen H. Leppla, Wei-Jen Tang, and Rustem F. Ismagilov, Nature Chemical Biology 2008 4:742-750

7. Feng Shen, Christian J. Kastrup, Ying Liu, and Rustem F. Ismagilov, Arterioscler. Thromb. Vasc. Biol. 2008 28: 2035-2041

6. Feng Shen, Christian J. Kastrup, and Rustem F. Ismagilov, Thrombosis Research. 2008;122: S27-S30

5. Christian J. Kastrup, Feng Shen, Matthew K. Runyon, and Rustem F. Ismagilov, Biophysical Journal 2007 93:2969-2977

4. Christian J. Kastrup, Feng Shen, and Rustem F. Ismagilov, Angew. Chem. Int. Ed. 2007 46: 3660-3662 (Cover issue)

3. Christian J. Kastrup, Matthew K. Runyon, Feng Shen, and Rustem F. Ismagilov, Proceedings of the National Academy of Sciences 2006 103:15747-15752 (Cover issue)

2. Xueshu Li, Feng Shen, Hua Fu, Yuyang Jiang, Yufen Zhao. Synlett. 2006; 4: 630-632

1. Xueshu Li, Dongwei Zhang, Hai Pang, Feng Shen, Hua Fu, Yuyang Jiang, Yufen Zhao. Organic Letters. 2005; 7: 4919-4922

Contact

E-mail：feng.shen@sjtu.edu.cn

address：教三楼 213室

website：https://www.x-mol.com/groups/shenfeng_sjtu