Yani Kang

Yani Kang joined Shanghai Jiao Tong University in 2010. During the past few years, she has being involved in developing and applying cutting-edge high throughput genomic technologies to explore genome function.Her research interests include: 1) Mechanism of antitumor drugs; 2) Epigenetics in stem cell; 3)Transcriptional network in tumor cell. She has published more than 20 papers and carried out several projects by NSFC, 973 Program and SATCM foundations as a key staff or major participant.

Research Project
Monograph

1. Gao QH, Wen B, Kang Y*, Zhang WM*. Pump-free microfluidic magnetic levitation approach for density-based cell characterization. Biosens Bioelectron. 2022 May 15; 204:114052. 

2. Zhao H, Zhang H, Xu W, Wen B, Kang Y*. A Sight of the Diagnostic Value of Aberrant Cell-Free DNA Methylation in Lung Cancer. Dis Markers. 2022 Jan 27;2022:9619357. 
3. Yu B, Zhu N, Fan Z, Li J, Kang Y*, Liu B*. miR-29c inhibits metastasis of gastric cancer cells by targeting VEGFA. J Cancer. 2022 Otc 31; 13(14):3566-3574. 
4. Wang J#,  Qin Y#, Kang Y#, Li X, Wang Y,  Li H*, Daniel M.C*, Shao Z*. Temporal profiling with ultra-deep RRBS sequencing reveals the relative rarity of stably maintained methylated CpG sites in human cells. Acta Biochim Biophys Sin 2022, 54(12):1-4. 
5. Mao Z, Li T, Zhao H, Wang X, Kang Y, Kang Y*. Methylome and transcriptome profiling revealed epigenetic silencing of LPCAT1 and PCYT1A associated with lipidome alterations in polycystic ovary syndrome. J Cell Physiol. 2021;236:6362-6375. 
6. Mao Z, Li T, Zhao H, Qin Y, Wang X, Kang Y*. Identification of epigenetic interactions between microRNA and DNA methylation associated with polycystic ovarian syndrome. J Hum Genet. 2021,66(2):123-137.  
7. Qin Y, Li T, Zhao H, Mao Z, Ding C, Kang Y*. Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy. Front. Genet. 2021,12:620241.
8. Qin Y, Wang Y, Zhao H, Yang Z, Kang Y*. Aberrant miRNA-mRNA regulatory network in polycystic ovary syndrome is associated with markers of insulin sensitivity and inflammation. Ann Transl Med.2021;9(18):1405.
9. Mao Z, Zhao H, Qin Y, Wei J, Sun J, Zhang W, Kang Y*. Post-Transcriptional Dysregulation of microRNA and Alternative Polyadenylation in Colorectal Cancer. Frontiers in Genetics. 2020, 11:64.
10.Wei J , Gao X, Qin Y, Liu T, Kang Y*. An iron metabolism-related SLC22A17 for the prognostic value of gastric cancer. OncoTargets and Therapy, 2020:13 12763-75.


Patent

国家技术发明专利:

1. 一种用于肺癌预后诊断标志物的应用及检测试剂盒,授权专利号:CN 113151462 B

2. 诊断结直肠癌的分子组合标志物及检测试剂盒,授权专利号:CN110241211B

3. 一种从卵泡液中提取cfDNA的方法,授权专利号:CN110144345B

4. 一种微量DNA样品高通量测序文库的构建技术,授权专利号:CN 109023537 B

5. 一种用于DNA甲基化检测的试剂盒与方法及应用,授权专利号:CN108796039B

6. 一种检测蛋白质和DNA相互作用的试剂盒与方法及应用,授权专利号:CN108680757B

7. 红藻龙须菜多糖及其制备、抗肿瘤活性检测方法和应用,授权专利号:CN105542024B

8. 基于3T-seq全基因组范围分析APA的方法,授权专利号:CN103911449B

9.DNA甲基化标志物LPCAT1在制备诊断PCOS试剂盒中的应用,公布号:CN111254192A

10.用于PCOS诊断的颗粒细胞生物标志物及其筛选方法和诊断试剂盒,公布号:CN110747269A

Contact

E-mail:kangyani@sjtu.edu.cn

address:闵行校区文选医学楼126