School of biomedical engineering, Shanghai jiaotong university

Shiyi Zhang

Shiyi Zhang has been a tenure track associate professor in the School of Biomedical Engineering at the Shanghai Jiao Tong University since 2016. He obtained his bachelor’s degree from Peking University in Beijing in 2008. After then, he started his Ph.D. study with Prof. Karen Wooley at the Washington University in St. Louis. His PhD research interests ranged from degradable polymer for nanomedicine to the polymer self-assembly for functional nanostructures. Upon the completion of his PhD research in 2013, he arrived at MIT as a Max-Planck Postdoctoral Fellow with Prof. Robert S. Langer, focusing the translational study for gastrointestinal drug delivery. Zhang’s research appears in more than forty articles in leading journals, including Nature Materials, Science Translational Medicine, Science Advances, Nature Communications, eLife, Journal of the American Chemical Society, ACS Nano, Advanced Materials, Advanced Functional Materials, Macromolecules and ACS Macro Letters, and results more than twenty patent applications. He also helped to build the biotech startup, Lyndra, to push the gastric retentive drug delivery system into Phase III clinical trial. He is the scientific founder of OnQuality Pharmaceuticals, a clinical stage biotech to develop innovative drugs that improve the quality of cancer patients’ lives. Dr. Zhang received 1000 Plan Program for Young Talents in 2015. His current research interests include: novel treatments for adverse effects caused by anti-cancer therapies and non-absorbable materials (polymeric or inorganic) as drugs for metabolic diseases.

Research

Novel treatments for adverse effects caused by anti-cancer therapies and non-absorbable materials (polymeric or inorganic) as drugs for metabolic diseases

Monograph

Tian, M.; Mu, X.; Fan, D.; Liu, Z.; Liu, Q.; Yue, K.; Song, Z.; Luo, J.; Zhang, S.* "A Transformable Mucoadhesive Microgel Network for Noninvasive Multimodal Imaging and Radioprotection of a Large Area of the Gastrointestinal Tract" Adv. Mater. , 2023 Accepted

Xiang, J.; Wang, H.; Tao, Q.; Li, W.; Huang, Y.; Zhang, Y.; Yang, L.; Zhang, S.* " CDK4/6 inhibitor modulating active and quiescent intestinal stem cells for prevention of chemotherapy-induced diarrhea" J. Pathol. , 2023 Accepted

Yang, B.; Xie, X.; Wu, Z.; Lv, D.;Hu, J.; Chen, Y.; Li, J.; Li, J.; Luo, S.; Luo, J.; Zhang, S.* "DNA damage-mediated cellular senescence promotes hand–foot syndrome that can be relieved by thymidine prodrug" Genes Dis. , 2022 Accepted

Yang, B.; Xie, X.; Lv, D.; Hu, J.; Chen, Y.; Wu, Z.; Luo, S.; Zhang, S.* "Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil" Br. J. Cancer, 2022 Accepted

Yang, J.; Wang, X.; Wang, B.*; Park, K.*; Wooley K. L.*; Zhang, S.* "Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers" Adv. Drug Deliv. Rev., 2022 109, 114525

Tian, M.; Fan, D.; Liu, Z.; Mu, X.; Tao, Q.; Yu, C.; Zhang, S.* "Oral Supramolecular Adsorbent for Preventing Chemo-Induced Gastrointestinal Mucositis & Microbial Dysbiosis and for Enhancing Chemoimmunotherapy" Adv. Mater., 2022 Accepted

Chen, L.; You, Q.; Liu, M.; Li, S.; Wu, Z.; Hu, J.; Ma, Y.; Xia, L.; Zhou, Y.; Xu, N.*; Zhang, S.* "Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy" eLife, 2022 (11): e72443

Xie, X.; Chen, L.; Liu X.; Wu, Z.; Lv, D.; Ma, Y.; Luo, J.; Zhang, S.* "Prophylactic effect of nitric oxide donors on rat models of EGFR inhibitors induced-cutaneous toxicities" J. Invest. Dermatol., 2022. May 23; S0022-202X(22)00399-2.

Chen, L.; Wu, Z.; Yang, L.; Chen, Y.; Wang, W.; Cheng, L.; Li, C.; Lv, D.; Xia, L.; Chen, J.; Tang, L.*; Zhang, L.*; Zhang, S.*; Luo, J.* "Nitric Oxide in Multikinase Inhibitor-induced Hand-Foot Skin Reaction" Transl. Res., 2022, 245: 82-98

Chen, L.; You, Q.; Lv, D.; Li, S.; Zhang, S.* "GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib" Acta. Pharmacol. Sin., 2021, 43: 1534–1543

Tian, M.; Xing, R.; Guan, J.; Yang, B.; Zhao, X.; Yang, J.; Zhan, C.*; Zhang, S.* "A Nanoantidote Alleviates Glioblastoma Chemotoxicity without Efficacy Compromise" Nano Lett. 2021, 21, 12, 5158-5166

Zhao, X.; Zhang, H.; Li, J.; Tian, M.; Yang, J.; Sun, S.; Hu, Q.; Yang, L.; Zhang, S.*;"Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders" Sci. Adv., 2021, 7, 14, eabf7311

Bellinger, A. M.*; Jafari, M.*; Grant, T. M.*; Zhang, S. *; Slater, H.; Wenger, E.; Mo, S.; Lee, Y-A. L.; Mazdiyasni, H.; Kogan, L.; Barman, R.; Cleveland, C.; Booth, L.; Bensel, T.; Minahan, D.; Hurowitz, H. M.; Tai, T.; Daily, J.; Nikolic, B.; Wood, L.; Eckhoff, P.; Langer, R.; Traverso, G. "Oral, Ultra–long-lasting Drug Delivery: Application Toward Malaria Elimination Goals" Sci. Transl. Med. , 2016 16;8(365):365ra157 (* equal contribution)

Zhang, S.; Bellinger, A. M.; Glettig, D. L.; Barman, R.; Lee, Y.-A. L.; Zhu, J.; Cleveland, C.; Montgomery, V. A.; Gu, L.; Nash, L. D.; Maitland, D. J.; Langer, R.; Traverso G. "A pH-responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices" Nat. Mater., 2015, 14, 1065-1071

Contact

E-mail：zhangshiyi@sjtu.edu.cn

address：文选楼 442室