Wang, Yongting, Ph.D.

      Prof. Yongting Wang received her Ph.D. degree of Biochemistry from the University of Mississippi Medical Center in 2004. She studied protein subunit interaction and protein aggregation diseases as a post-doctoral fellow at MIT (2004-2008) before joining Med-X Research Institute of SJTU in 2008 as an Associate Professor (2008-2011). She is now a Professor in the School of Biomedical Engineering. Her research focuses on strategies that promote neurovascular remodeling and functional recovery after ischemic stroke. She developed gene therapy, stem-cell-combined gene therapy, and optogenetics techniques to enhance angiogenesis and neurogenesis in ischemic brain. As a principle investigator, Prof. Wang is supported by many research agencies including the NSFC and the Ministry of Science and Technology. She had published over 50 peer-reviewed research articles in high-impact journals including STROKE and JACS. She is the recipient of SMC Young Faculty Award (2009-2011) and Second Class Science and Technology Progress Award from the Ministry of Education (2013). She is also awarded the “NSFC Excellent Young Scientists Fund” this year, which funds only 400 scientists nationwide. She has been a member of the International Society for Cerebral Blood Flow & Metabolism and the American Heart and Stroke Association. She also serves as the Council Member of the Cerebral Blood Flow & Metabolism Branch of Chinese Stroke Association.

Research Interests:

Gene therapy and stem-cell-combined gene therapy for ischemic stroke; Real-time live imaging of the cerebral microvasculature of experimental animals

Selected Publications:

1.Li Y, Huang J, He X, Tang G, Tang YH, Liu Y, Lin X, Lu Y, Yang GY*, Wang Y*. Postacute stromal cell-derived factor-1α expression promotes neurovascular recovery in ischemic mice. Stroke. 2014;45(6):1822-9.

2.Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y*, and Yang GY*, Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4 Up-Regulation after Cerebral Ischemia. Stem Cells. 2014;32(12): 3150-62

3.Liu J*, Wang Y*, Akamatsu Y*, Lee CC, Stetler RA, Lawton MT, Yang GY. Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115C:138-156

4.He X, Li Y, Lu H, Zhang Z, Wang Y*, Yang GY*. Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2013;33(12): 1921-7.

5.Huang J, Li Y, Tang Y, Tang G, Yang GY*, and Wang Y*. CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response after Focal Ischemia in Mice. Stroke 2013 44(1): 190-7

Funding Agencies:

NSFC, Ministry of Science and Technology, Ministry of Education, STC of Shanghai Municipality, and SJTU

E-mail: ytwang@sjtu.edu.cn

Tel: 86-21-62933291