夏伟梁

博士,上海交通大学生物医学工程学院教授、博士生导师,致远学院副院长。曾于清华大学、香港大学、美国洛克菲勒大学及加州大学旧金山分校学习和深造。2008年底全职加入交大Med-X研究院从事生物医学研究和教学。获上海市科委“启明星”、上海交大晨星学者、唐立新学者等荣誉。中国细胞生物学学会青年工作委员会委员、美国癌症研究协会、国际大脑血流与代谢协会、中国细胞生物学学会、中国神经科学学会会员。主要研究方向: 肿瘤进展、治疗抵抗的机制及新靶点发现; 外泌体生物学及其应用; FGF/FGFR和Sirtuin在肿瘤和组织修复的作用。主持科技部973课题、国家自然科学基金委面上、医工交叉重点等项目。发表SCI收录学术论文约100篇,其中通讯或第一作者论文约70篇,H-因子37。

研究方向

肿瘤进展、治疗抵抗的机制及新靶点发现(Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets); 外泌体生物学及其应用(biology of exosome and applications); FGF/FGFR和Sirtuin在肿瘤和组织修复的作用(role of FGF/FGFR and sirtuin in cancer and tissue repair)。

科研项目
科技部973项目课题,国家自然科学基金委面上项目,上海交通大学医工交叉重点项目
代表性论文专著

1.      Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*. Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104. Oncogene. 2020; 37:3507–3521.

2.      Li F, Li X, Li Z, Ji W, Lu S, Xia W*. βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019; 9:7474-7489.

3.      Yan L, Li H*, Xia W*. Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity. Cell Prolif. 2020;53: e12906.

4.   Cheng Y, Zeng Q, Han Q, Xia W*. Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell. 2019; 10:295-299.

5.      Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W*, Gao WQ*. Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ.2019; 26:2479-2492.

6.      Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*.FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer. Oncogene. 2018;37:5340-5354.

7.      Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*. The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer. Cancer Lett. 2018; 423:36-46.

8.      Yang X, Geng K, Zhang Y, Zhang J, Shao J, Xia W*. Sirt3 deficiency impairs neurovascular recovery in ischemic stroke. CNS Neurosci Ther.2018;24:775-783.

9.      Zhang T, Yang X, Liu T, Shao J, Fu N, Yan A, Geng K, Xia W*.Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice. Stem Cell Res Ther. 2017, 8:248.

10.   Yang X, Geng K, Zhang J, Zhang Y, Shao J, Xia W*. Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. Front Pharmacol. 2017 Dec 22;8:943.

11.   Xia W*, Geng K. A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases. Semin Cell Dev Biol.2016;59:71-78.

12.   Shao J, Yang X, Liu T,Zhang T,Xie QR, Xia W*. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death. Protein Cell. 2016, 7:281-290.  

13.   Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*.Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier.Biomaterials. 2014;35:10058-10069.

联系方式

邮箱地址:wlxia@sjtu.edu.cn

联系电话:86-21-62933351

办公地址:教三楼 211室