• 张岩

    副研究员(院特别研究员),博士生导师。           

    山东医科大学学士,山东大学博士,美国纽约大学和康奈尔大学博士后。

    以第一或通讯作者在Cell Research、Circulation、Advanced Science、Cancer Research、Cancer Letters、Oncoimmunology、Clin Transl Med 等国际著名期刊发表近20篇SCI论文, 累计影响因子大于200。

    主持国家级项目(重点研发计划,国家自然科学基金面上项目,青年项目)7项和省部级项目6项。

    国际学术期刊Global Medical Genetics 编辑,Front Cell Dev Biol、Cancer Manag Res和Transl Oncol特约审稿人。受邀为国家自然科学基金及多家科学杂志等评审。

研究方向

智慧免疫:疾病相关免疫细胞的分化和极化的机制研究;AI+免疫
免疫工程:用于细胞治疗的合成免疫学研究


代表性论文专著

1. Zhang Y*, Wang ZE, Lu Y, Sanchez J.D, Li JJ, Wang LH, Meng XX, Zhong M*, Gao WQ*, Ding XT*. Region-specific CD16+ neutrophils promote colorectal cancer progression by inhibiting natural killer cells, Advanced Science, 2024, 11(29):e2403414    (IF=15.1)

2. Lin HP, Luo Y, Gong TY, Fang HS, Li H, Ye GY, Zhang Y*, Zhong M*. GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer, Cell Oncolgoy, 2024, 47(4):1149  (IF=4.9)

3. Qu JW, Li DW, Jin JS, Sun N, Wu JJ, Zhang Y*, Yuan XD*, Zhang M*. Hypoxia-Inducible Factor 2a Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Mode Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice, J Am Soc Nephrol, 2023, 34(1):73 (IF=8.65)

4. Wang C, Zhang Y*, Gao WQ*. The involving role of immune cells in prostate cancer, Cancer Letters, 2022, 252:9-12    (IF=9.7)

5. Fang HS#Huang YZ#Luo Yang # Tang JYYu MHZhang Y*Zhong M*, SIRT1 induces the accumulation of TAMs at colorectal cancer tumor sites via the CXCR4/CXCL12 axis. Cell Immunology, 2022, 371:104458     (IF=4.868)

6. Xu YJ#, Chen JJ#, Huang YZ, Luo Y, Hsieh AC, Li H, Wei XB*, Gao WQ*, Zhong M*, Zhang Y*. Patient-derived organoids in cellulosic sponge model chemotherapy response of metastatic colorectal cancer, Clin Transl Med, 2021, 11(1):e285    (IF=11.492)

7. Fang HS#Huang YZ#Luo Yang # Tang JYYu MHZhang Y*Zhong M*, SIRT1 induces the accumulation of TAMs at colorectal cancer tumor sites via the CXCR4/CXCL12 axis. Cell Immunology, 2022, 371:104458     (IF=4.868)

8. Lu Y #, Huang YZ #, Huang Lei #, Xu YJ, Wang ZE, Li H, Zhang T, Zhong M*, Gao WQ*, Zhang Y*. CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients, BMC Immunology, 2020, 21;46   (IF=3.615)

9. Wang Chao; Chen Jiahuan; Zhang Qianfei; Li Wang; Zhang Shengbo; Xu Yanjie; Wang Fang; Zhang Bing; Zhang Yan*; Gao Wei-qiang*; Elimination of CD4lowHLA-G+ T cells overcomes castrationresistance in prostate cancer therapy, Cell Research, 2018, 28(11): 1103-1117   (IF=11.615)


联系方式

邮箱地址:yanzh@sjtu.edu.cn

办公地址:教三楼 308