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  郭妍

  副研究员，硕士生导师。在东南大学获得本科和硕士学位（1998-2001），上海交通大学生物化学与分子生物学博士学位（2001-2005），同年进入系统生物医学研究院工作（2005-2013）。2009年起担任副研究员。主要研究兴趣为：建立和利用基于激光显微切割的空间系统生物学方法（特别是在单细胞尺度上的空间基因组和空间转录组方法），研究胃癌发生和发展的分子机制以及器官发育的基因转录调控。已发表科研论文28篇。作为项目负责人承担国家自然科学基金重大研究计划，面上项目，青年基金等，参与多项课题研究。

1：建立基于激光显微切割的空间系统生物学方法（特别是单细胞尺度的基因组和转录组方法）

2：胃癌的发生和发展机制

3：器官发育的转录调控网络

1. Jiangrong Chen*, Chunchao Zhu*, Chaojie Wang*, Chuansheng Hu, Daniel M Czajkowsky, Yan Guo^#, Bingya Liu^#, Zhifeng Shao^#, Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands. Journal of Medical Genetics. 2019; 0: 1-4

2. Yan Guo, Ayuan Huang, Chuansheng Hu, Yan Zhou, Xiaodan Zhang, Daniel M. Czajkowsky, Jianfang Li, Shidan Cheng, Ruizhe Shen, Jianren Gu, Bingya Liu, Zhifeng Shao, Complex clonal mosaicism within microdissected intestinal metaplastic glands without concurrent gastric cancer, Journal of Medical Genetics. 2016; 53: 643-646

3. Guo Y*, Zhou J*, Huang AY, Li JF, Yan M, Zhu ZG, Zhao XD, Gu JR, Liu BY, Shao ZF, Spatially defined microsatellite analysis reveals extensive genetic mosaicism and clonal complexity in intestinal metaplatic glands, International Journal of Cancer, 2015, 136(12), 2973-2979

4. Yan Guo, Yi Yang, Juan Zhou, Daniel M. Czajkowsky, Bingya Liu, Zhifeng Shao, Microdissection of spatially identified single nuclei in a solid tumor for single cell whole genome sequencing, Biotechniques, 2012, 0(0): 1-3.

5. Runsheng Li*, Yan Guo*, Bang Ming Han, Xiaowei Yan, Angelita G. Utleg, Wei Li, Lan Chun Tu, Jian Wang, Leroy Hood, Shujie Xia, Biaoyang Lin, Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates, Proteomics Clin. Appl. 2008, 2, 543–555