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  张春富

  上海交通大学生物医学工程学院教授， 2002年获中国科学院工学博士学位，并获中国科学院院长优秀奖。曾先后于德国癌症研究中心(DKFZ)和美国德州大学西南医学中心(UT Southwestern Medical Center)进行博士后研究。2008年4月加入上海交通大学，主要从事多模态纳米分子影像探针技术及肿瘤诊疗研究和放射性药物及临床应用研究。目前作为第一或通讯作者发表包括Cancer Research, ACS Nano, Advanced Functional Materials, Exploration，Advanced Science, Radiology，Nano Today, Biomaterials等文章110余篇，授权发明专利5项。曾先后获得上海市科学技术进步奖一等(R2)、二等奖各一项(R2)，教育部自然科学奖二等奖。目前为包括Nanomedicine: Nanotechnology Biology and Medicine在内多个英文杂志编委。担任Advanced Materials、ACS Nano、Advanced Functional Materials、Journal of American Chemical Society、Small、Theranostics等二十多个期刊特约审稿人。先后获得四项国家自然基金项目研究，目前参与科技部重点研发计划课题、承担国家自然基金项目和上海市科委课题的研究。

       1、多模态纳米分子影像探针技术及肿瘤诊疗研究

       2、放射性药物及临床应用研究

1、国家自然科学基金委员会，面上项目，81571729，基于密度泛函理论金原子簇放射性药物设计、制备及其在肺癌诊疗中的应用研究，2024-01至2027-12，48万，主持

2、国家重点研发计划“合成生物学”重点专项项目“消化系统肿瘤高特异分子探针的创制与临床转化研究”，项目编号：2020YFA0909000；起止时间：2020 年 11 月–2025 年 10 月。参与（骨干）。

3、国家自然科学基金委员会，面上项目，81571729，基于上海同步辐射光源同轴相衬成像双模双靶向肺癌早期诊断研究，2016-01至2019-12，57万，主持。

4、国家自然科学基金委员会，重点项目，81230030，高靶向 PET/MRI 双模态分子显像探针构建及在肺癌早期诊断中的应用研究，2013-01至2017-12, 280万，参与（合作申请）。

5、国家自然科学基金委员会，面上项目，30870682，超灵敏及特异性磁共振分子显像纳米探针研制及其在肺癌早期诊断中应用研究，2009-01至2011-12, 32万，主持。

6、国家自然科学基金委员会，青年基金，10405034，生物磁靶向纳米放射性免疫药物的研究，2005-01至2007-12，26万，主持。

5年内代表性论文：

1. Yifei Jiang, Huizhen Yang, Guoping Jia, Wangxi Hai, Rongyi Huang, Peng Wang, Min Zhang, Danni Li, Yizhou Chen, Xiao Li*, Biao Li*, Chunfu Zhang*. Ultrasmall Au_10–12 Nanoclusters: A Novel Platform for ²²³ Ra-Targeted Tumor α-Therapy.  Exploration, 2026; 6:70144. 

2. He Gao, Yifei Jiang, Ying Miao, Huizhen Yang, Guoping Jia, Xinyu Zhang Runhua Feng, Zhenggang Zhu, Wangxi Hai, Xiaozheng Zhang, Peng Wang, Min Zhang, Xiao Li*, Biao Li*, Chunfu Zhang*.  A ⁶⁸Ga/¹⁶¹Tb-labeled FAP-targeted radioligand for enhanced theranostics: Prolonged tumor retention and metastasis inhibition. Journal of Controlled Release 2026, 399, 115298. 

3. Guoping Jia, Huizhen Yang, Qinghe Wu, Yifei Jiang, He Gao, Xubo Wu, Zhiyuan Xie, Haizhen Jin, Jia Xu*, Chunfu Zhang*. Immunomodulator triptolide synergizes with black phosphorus nanosheets-mediated calcium overload for mild heat-potentiated cancer immunotherapy. Chemical Engineering Journal 2026, 547, 180969. 

4. Huizhen Yang, Liu Liu, Guoping Jia, He Gao, Wangxi Hai, Qinghe Wu, Jia Xu , Yifei Jiang*, Chunfu Zhang*. FAP-targeted gold nanocluster-mediated radioligand therapy in combination with TGF-βRI inhibition for tumor therapy. Biomaterials, 2027, 338, 124605.

5. Junjie Shen, Guoping Jia, Qinghe Wu, Huizhen Yang, Yifei Jiang, Xubo Wu, Yimin Chai, Chunfu Zhang*, Jia Xu*. Black phosphorus nanosheets fortified with catalase to enhance Schwann cell responses for neural repair. Journal of Controlled Release 2025, 380, 579–598. 

6. Xubo Wu, Qinghe Wu, Mengfei Hou, Yifei Jiang, Meng Li, Guoping Jia, Huizhen Yang, Chunfu Zhang*. Regenerating Chemotherapeutics through Copper-Based Nanomedicine: Disrupting Protein Homeostasis for Enhanced Tumor Therapy. Advanced Healthcare Materials. 2024, 2401954. 

7.  Yifei Jiang, Anqi Wang, Qinghe Wu, Guoping Jia, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang*. ⁸⁹Zr-Labeled pH-Responsive Gold Nanoclusters for Radiosensitization Therapy of Tumors. ACS Appl. Nano Mater. 2024, 7, 15325−15333. 

8. Guoping Jia, Qinghe Wu, Mengfei Hou, Yifei Jiang, Huizhen Yang, Meng Li, Xubo Wu, and Chunfu Zhang*. Ultrathin BSA-Stabilized Black Phosphorous Nanoreactor Boosts Mild-Temperature Photothermal Therapy Through Modulation of Cellular Self-Defense Fate. Advanced Healthcare Materials 2024, 13(31), 2402079. 

9. Mengfei Hou, Haiyang Su, Qinghe Wu, Wenshe Sun, Pengli Zhang, Yifei Jiang, Kun Qian * and Chunfu Zhang*. A Self-Enhancing Nanoreactor Reinforces Radioimmunotherapy by Reprogramming Nutrients and Redox Metabolisms. Advanced Functional Materials 2023, 33(16), 2212510.  

10.  Meng Li, Mengfei Hou, Qinghe Wu, Yifei Jiang, Guoping Jia, Xubo Wu, and Chunfu Zhang*. Simultaneous Inhibition of Heat Shock Response and Autophagy with Bimetallic Mesoporous Nanoparticles to Enhance Mild-Temperature Photothermal Therapy. Small Structures 2023, 4(11), 2300132.

11.  Yifei Jiang, Qinghe Wu, Mengfei Hou, Wangxi Hai, Min Zhang, Biao Li, Chunfu Zhang*. pH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor. Materials Today Bio 2023,19, 100578.

12.  Qinghe Wu, You Zhang, Guoping Jia, Mengfei Hou, Yifei Jiang, Weijun Wei, Ping Liu, Gang Huang, Jianhua Zou, Jingjing Zhang, Wangxi Hai, Min Zhang, Biao Li, Xiaoyuan Chen*, Chunfu Zhang*. A sequential dual-locked strategy with pH-responsive activation of photosensitizers and precise Cerenkov radiation delivery for cancer theranostics. Nano Today 2023, 52, 101984.

13.  Feng Wang, Qinghe Wu, Guoping Jia, Lingchi Kong, Rongtai Zuo, Kai Feng, Mengfei Hou, Yimin Chai, Jia Xu,* Chunfu Zhang,* and Qinglin Kang*. Black Phosphorus/MnO₂ Nanocomposite Disrupting Bacterial Thermotolerance for Efficient Mild-Temperature Photothermal Therapy. Advanced Science 2023, 2303911.