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  汤耀辉

  长聘教轨副教授，博士生导师，科技部国家重点研发计划首席青年科学家，2019年度中国卒中学会优秀科技工作者，2021年度上海市青年科技启明星（A类）。于2014年获得上海交通大学生物医学工程学院博士学位。2014-2018年先后在德国马克思普朗克研究所、美国斯坦福大学从事博士后研究。2018年3月担任上海交通大学生物医学工程学院长聘教轨助理教授，同时担任Stroke and Vascular Neurology的Assistant Editor以及多本SCI杂志编委（Frontiers in cellular Neuroscience, Current stem cell research and therapy等）；长期从事神经生物学和神经病学，特别是脑血管疾病的转化医学研究。目前主持国家重点研发计划“干细胞与转化研究”青年项目、国家自然科学基金、上海交通大学医工交叉重点基金等，在Nature Communications, Advanced Science, Nano Today, Advanced functional materials, Stroke，Journal of cerebral blood flow and metabolism，Stem Cell Reports等国际重要期刊上共发表SCI论文40余篇，总影响因子400余分，H-因子27，引用2400余次。 

  
  

2005.9-2009.7   北京林业大学               学士

2009.9-2014.7   上海交通大学               博士

2014-2018年先后在德国马克思普朗克研究所、美国斯坦福大学从事博士后研究。2018年3月担任上海交通大学生物医学工程学院特别副研究员，同时担任多本SCI杂志编委（Frontiers in cellular Neuroscience, Current stem cell research and therapy, ARC journal of neuroscience, Sciencematters等）；长期从事神经生物学和神经病学，特别是脑血管疾病的转化医学研究。

脑血管病的发病机制；胶质细胞在脑血管病中的作用；干细胞和外泌体治疗缺血性脑卒中；组织工程

主持基金项目：

1. 上海市“科技创新行动计划”启明星项目（A类）, 2021/07-2024/06

2.  国家自然科学基金面上项目，2021/01-2024/12

3. 国家重点研发计划重点专项青年项目, 2019/09-2023/12

4. 国家自然科学基金青年项目，2019/01-2021/12

5. 上海交通大学医工交叉重点基金，2019/01-2021/12

6. 上海交通大学医工交叉青年基金A，2019/01-2021/12

7. 上海交通大学医工交叉青年基金B，2019/01-2021/12

参与基金项目：

1. 上海市教育委员会科研创新计划项目，2019/01-2023/12

2. 国自然重点，2020/01-2024/12

1. Xiaojing Shi#, Longlong Luo#, Jixian Wang#, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon Hyuk Lee, Hengli Tian, Zhijun Zhang, Yongting Wang, Won-Suk Chung*, Yaohui Tang*, and Guo-Yuan Yang*. (Co-corresponding author) Stroke subtype-dependent synapse elimination by reactive gliosis in mice. Nature Communications. 2021. Accepted. (IF:17.694)

2.  Fengzhen Cui, Qingfei Pan, Siyi Wang, Faming Zhao, Runxin Wang, Tingting Zhang, Yaying Song, Jun He, Haolin Zhang, Qiang Weng, Yang Jin, Wei Xia, Yuanyuan Li, Guo-Yuan Yang, Winnok De Vos, Jean-Pierre Timmermans, Shunqing Xu*, Yaohui Tang* and Xia Sheng*. (Co-corresponding author) Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring. Advanced Science, 2021: e2102686. (IF: 17.521) 

3.  Cheng Wang#, Xuewei Yang#, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian, Qingqing Yin, Li Li, Zhijun Zhang, Yongting Wang, Guo-yuan Yang, Yijie Chen*, Yaohui Tang*.  (Co-corresponding author) Targeted Delivery of Fat Extract by Platelet Membrane-Cloaked Nanocarriers for the Treatment of Ischemic Stroke. Journal of Nanobiotechnology. 2022 May 31;20(1):249. (IF:10.435)

4. Huitong Ruan#, Yongfang Li#, Cheng Wang, Yixu Jiang, Yulong Han, Yiwei Li, Dandan Zheng, Jing Ye, Gang Chen, Guo-yuan Yang, Lianfu Deng, Ming Guo, Xingcai Zhang*, Yaohui Tang*, Wenguo Cui*.  (Co-corresponding author)  Click Chemistry Extracellular Vesicle /Peptide/Chemokine Nanomissiles for Treating CNS Injuries. Acta Pharmaceutica Sinica B. 2022, Accepted. (IF:14.903)

5. Qi Zhang#, Chang Liu#, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng, Tingting Chen, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang*, Yaohui Tang*. (Co-corresponding author) Blocking C3d +/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke. Aging and disease. (IF:9.968)

6. Ming Ma, Yimeng Shua, Yaohui Tang* and Hangrong Chen*.  (Co-corresponding 

author) Multifaceted application of nanoparticle-based labeling strategies for stem cell 

therapy. Nano Today 34, 100897. (IF:20.722)

7. Minghua Yao, Xiaojing Shi, Changjing Zuo, Ming Ma*, Lu Zhang, Hongbo Zhang, Xin Li,

Guo-Yuan Yang, Yaohui Tang*, Rong Wu*. (Co-corresponding author) Engineering of 

SPECT/Photoacoustic Imaging/Antioxidative Stress Triple-Function Nanoprobe for Advanced 

Mesenchymal Stem Cell Therapy of Cerebral Ischemia. ACS Appl Mater Interfaces. 2020 Aug 

26;12(34):37885-37895. (IF:10.383)

8. Yaohui Tang, Xinming Tong, Bogdan Conrad and Fan Yang. Injectable and in situ 

Crosslinkable Gelatin Microribbon Hydrogels for Stem Cell Delivery and Bone Regeneration in 

vivo. Theranostics 2020; 10(13): 6035–6047. (IF: 11.6)

9. Pengju Zhang*, You Li*, Yaohui Tang*, Hui Shen, Jiankai Li, Zhengfang Yi, Qinfei Ke and He Xu. (Co-first author) Copper-Based Metal-Organic Framework as A Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing. ACS Applied Materials & Interfaces. 2020 Apr 22;12(16):18319-18331. (IF:10.383)

10. Hui-Min Shan, Minhua Zang, Qi Zhang, Ru-Bing Shi, Xiao-Jing Shi, Muyassar Mamtilahun, Chang Liu, Long-long Luo, Xiaoying Tian, Zhijun Zhang, Guo-Yuan Yang, Yaohui Tang*, Jun Pu*, Yongting Wang*. (Co-corresponding author) Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice. J Neuroinflammation. 2020; 17: 164. (IF:9.587)

11. Yaying Song, Zongwei Li, Tingting He, Meijie Qu, Lu Jiang, Wanlu Li, Xiaojing Shi, Jiaji Pan, Linyuan Zhang, Yongting Wang, Zhijun Zhang*, Yaohui Tang*  and Guo-Yuan Yang*.  (Co-corresponding author) M2 microglia-derived exosomes protect the mousebrain from ischemia-reperfusion injury via exosomalmiR-124. Theranostics. 2019; 9(10):2910-2923. (IF:11.6)

12. Meijie Qu, Jiaji Pan, Liping Wang, Panting Zhou, Yaying Song, Shuhong Wang, Lu Jiang, JieliGeng, Zhijun Zhang, Yongting Wang, Yaohui Tang* and Guo-Yuan Yang*. (Co-corresponding author) MicroRNA-126 regulates angiogenesis and neurogenesis in a mouse model of focal cerebral ischemia. Molecular Therapy-Nucleic Acid. 2019 Feb 11;16:15-25. (IF:10.183)

13. Yaohui Tang,Chunfu Zhang, Jixian Wang, Xiaojie Lin, Lu Zhang, Yi Yang, Yongting Wang, Zhijun Zhang, Jeff W.M. Bulte, Guo-Yuan Yang. MRI/SPECT/Fluorescent tri-Modal probe for evaluating the homing and therapeutic efficacy of transplanted mesenchymal stem cells in a rat ischemic stroke model. 2015. Advanced Functional Materials. Feb; 25(7):1024-34 (IF：19.924) 

生物学导论，32学时，本科生

神经生物学实验基础，32学时，研究生

学术报告会，32学时，研究生

2022.7-至今      Stroke and Vascular Neurology                                 Assistant Editor

2016.7 -  至今    Frontiers in cellular neuroscience                                  编委

2019.11- 至今    Current Stem Cell Research & Therapy                          编委

2019.6 -  至今    中国卒中协会脑血流与代谢分会                                   委员

2019.10- 至今    上海市实验动物学会教育培训和科普专业委员会             委员

2019. Stroke conference, Early Career Investigator Award

Brain 2019 Young Investigator award

2019年度中国卒中学会优秀科技工作者

2020 上海市青年科技启明星（A类）