王永亭博士，上海交通大学教授，博士生导师。于1997年和2000年分别获得吉林大学生物技术学士和生物化学硕士学位。2004年获美国密西西比大学医学院生物化学博士学位，2004-2008年在美国麻省理工学院从事博士后研究。2008年加入上海交通大学Med-X研究院。主要进行缺血性脑卒中的基因治疗和干细胞联合基因治疗的基础和临床前研究。在JACS, Stroke，JCBFM等国际重要期刊上共发表SCI论文50余篇，总影响因子200余分。获上海交通大学“晨星优秀青年教师奖”(2009-2011)。作为第二完成人获得2013年教育部自然科学二等奖。主持国家自然科学基金青年基金和面上项目，2015年获得优秀青年基金资助。

主要研究领域：

基因治疗和干细胞联合基因治疗缺血性脑卒中；实验动物脑微血管结构功能的实时动态研究

五篇代表性研究论文：

1.Li Y, Huang J, He X, Tang G, Tang YH, Liu Y, Lin X, Lu Y, Yang GY*, Wang Y*. Postacute stromal cell-derived factor-1α expression promotes neurovascular recovery in ischemic mice. Stroke. 2014;45(6):1822-9.

2.Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y*, and Yang GY*, Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4 Up-Regulation after Cerebral Ischemia. Stem Cells. 2014;32(12): 3150-62

3.Liu J*, Wang Y*, Akamatsu Y*, Lee CC, Stetler RA, Lawton MT, Yang GY. Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115C:138-156

4.He X, Li Y, Lu H, Zhang Z, Wang Y*, Yang GY*. Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2013;33(12): 1921-7.

5.Huang J, Li Y, Tang Y, Tang G, Yang GY*, and Wang Y*. CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response after Focal Ischemia in Mice. Stroke. 2013;44(1): 190-7

科研项目：

主持自然科学基金青年基金、面上项目，优秀青年基金各一项，主持上海市自然科学基金项目一项，参加973项目课题两项，主持和参与SJTU医工交叉基金3项。

电子邮箱：ytwang@sjtu.edu.cn

办公电话：86-21-62933291

Wang, Yongting, Ph.D.

       Prof. Yongting Wang received her Ph.D. degree of Biochemistry from the University of Mississippi Medical Center in 2004. She studied protein subunit interaction and protein aggregation diseases as a post-doctoral fellow at MIT (2004-2008) before joining Med-X Research Institute of SJTU in 2008 as an Associate Professor (2008-2011). She is now a Professor in the School of Biomedical Engineering. Her research focuses on strategies that promote neurovascular remodeling and functional recovery after ischemic stroke. She developed gene therapy, stem-cell-combined gene therapy, and optogenetics techniques to enhance angiogenesis and neurogenesis in ischemic brain. As a principle investigator, Prof. Wang is supported by many research agencies including the NSFC and the Ministry of Science and Technology. She had published over 50 peer-reviewed research articles in high-impact journals including STROKE and JACS. She is the recipient of SMC Young Faculty Award (2009-2011) and Second Class Science and Technology Progress Award from the Ministry of Education (2013). She is also awarded the “NSFC Excellent Young Scientists Fund” this year, which funds only 400 scientists nationwide. She has been a member of the International Society for Cerebral Blood Flow & Metabolism and the American Heart and Stroke Association. She also serves as the Council Member of the Cerebral Blood Flow & Metabolism Branch of Chinese Stroke Association.

Research Interests:

Gene therapy and stem-cell-combined gene therapy for ischemic stroke; Real-time live imaging of the cerebral microvasculature of experimental animals

Selected Publications:

1.Li Y, Huang J, He X, Tang G, Tang YH, Liu Y, Lin X, Lu Y, Yang GY*, Wang Y*. Postacute stromal cell-derived factor-1α expression promotes neurovascular recovery in ischemic mice. Stroke. 2014;45(6):1822-9.

2.Tang G, Liu Y, Zhang Z, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y*, and Yang GY*, Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4 Up-Regulation after Cerebral Ischemia. Stem Cells. 2014;32(12): 3150-62

3.Liu J*, Wang Y*, Akamatsu Y*, Lee CC, Stetler RA, Lawton MT, Yang GY. Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115C:138-156

4.He X, Li Y, Lu H, Zhang Z, Wang Y*, Yang GY*. Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2013;33(12): 1921-7.

5.Huang J, Li Y, Tang Y, Tang G, Yang GY*, and Wang Y*. CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response after Focal Ischemia in Mice. Stroke 2013 44(1): 190-7

Funding Agencies:

NSFC, Ministry of Science and Technology, Ministry of Education, STC of Shanghai Municipality, and SJTU

E-mail: ytwang@sjtu.edu.cn

Tel: 86-21-62933291