Med-X 医工交叉高峰系列论坛

论坛时间：

2023年6月13日下午14：00——17：00

论坛地点：

上海交通大学徐汇校区Med-X楼 一楼会议室

腾讯会议号：249 264 644

会议密码：159101

入会链接：

https://meeting.tencent.com/dm/a1CESJ4jRBiE

论坛议程

• 14：00 - 14：05   院情介绍 丁显廷

• 14：05 - 14：50   MAPK and WNT Signals Meet at the Intestinal Stromal-epithelial Stem Cell Niche 苏冰

• 14：50 - 15：35   Various Roles of Dual-specificity Phosphatases (DUSPs) in Cancer 章勇良

• 15：35 - 17：00   交流讨论

报告摘要

报告一： MAPK and WNT Signals Meet at the Intestinal Stromal-epithelial Stem Cell Niche

报告二：Various Roles of Dual-specificity Phosphatases (DUSPs) in Cancer 

Cancer development is underlain by various genetic mutations which drive uncontrolled cell growth and resistance to apoptosis. The mutations in the RAF/RAS/MEK/ERK pathways are frequently found in various types of cancer where the constitutive activation of ERK promotes cancer cell growth, survival and tumorigenesis. The dual-specificity phosphatases (DUSPs) are the major negative regulators of MAP kinases including ERK, JNK and p38. These evolutionary conserved phosphates dephosphorylate the Serine/threonine and tyrosine residues in their substrates. Studies including ours showed that in addition to MAP kinases, these DUSPs are able to regulate the phosphorylation and activation of other important signaling molecules such as IRF3 and STAT3. Our investigation on the roles of several DUSPs including DUSP4, DUSP6, DUSP10 and DUSP16 showed their important function in cancer development and cancer response to treatment. In this talk, I will use two of our studies, the regulatory function of DUSP6 and DUSP16 in cancer, to show the various roles of DUSPs in cancer through differential mechanisms.

供稿单位：科研与学科办公室

作者：李鑫

审核：丁显廷